Transcript C2V 200: a new Nessi compatible microGC

C2V-200: a new Nessi compatible fast Micro GC
IFPAC, Baltimore 2008
C2V BV, Enschede, The Netherlands
IFPAC 2008
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Job Elders, PhD
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CEO of C2V
Ex GM for Alcatel Optronics NL with fiduciary responsibility
Founder of TMP (Total Micro Products)
Member of NanoNed Industrial Advisory Board & Invited referee of
Dutch Nanotechnology programme (€ 245M)
Invited member of advisory board of Point One (€ 500M Philips,
ASML, Economic Affairs program)
Member of program committee IOP precision technology
Advisor of Technology Accelerator of University of Twente
Co-chair of the international MANCEF MEMS Roadmap
(http://www.mancef.org)
Board member of the international magazine “Micro Nano”,
Executive board member and founder of MANCEF
Member of the Management of Technology Advisory Board of the
Anderson school of Management, University of New Mexico
Author of about 75 patents, technical and business papers
PhD in Physical Chemistry, University of Amsterdam
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Board member of Dosimetrix LLC
Board member of foundation “Kokopelli”
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Key historical milestones
2007
1991
2000
2002
BBV founded
BBV and TMP
acquired by
Kymata
Management
C2V successfully prebuy-out of AONL launches its Micro
to form C2V
Gas Chromatograph
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2005
Customer
Shipments
(Eng. Prototypes)
1995
2001
2003
2006
TMP founded
BBV Software
launched
Kymata acquired by
Alcatel. BBV and
TMP integrated to
form Alcatel
Optronics NL
C2V re-aligned to
market demand
Product introduction
Beta site testing
OEM product
evaluation
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C2V’s fast micro GC: enables Nessi compatibility
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2000-2002: NeSSI Generation I
– mechanical, passive components are on a SP76 substrate
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2002-2004: NeSSI Generation II
– “electrified” passive & active components are on a SP76
substrate
– integral heating and temperature control of the substrate
– all electrical components are integrated with SAM
– sensors and actuators communicate via sensor bus
– smart (self-diagnostic) sample systems
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2005+: NeSSI Generation III
– C2V-200: first high quality SP76 compatible microGC
– C2V-200: micro analyzer adds value to NESSI platform
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2007: Tipping point - First large scale commercial application:
– Exxon together with Siemens implements Nessi compatible
sample conditioning for SPT (Singapore Parallel Train –
chemical plant in Singapore)
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Fast micro GC vs. conventional GC
Technical Features / Benefits
Conventional GC
(Macro drawbacks)
Fast micro GC Cartridge
(Micro advantages)
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Life-time
Reliability
Reproducibility
Calibration (s)
Quantitation (ppm)
Consumables
Limited life-time
(6 months)
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System loading x10<
IC derived manufacturing
IC-based tolerances, QA/QC
Highly controlled operating
parameters (temperature, flow, etc.)
• Highly stable system performance
• Longer life-time, lower flow rates,
Extended life-time
(2-5 years)
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Fast micro GC versus conventional GC
Technical Features / Benefits
Conventional GC
(Macro drawbacks)
Fast micro GC Cartridge
(Micro advantages)
• System pre-programmed
• Requires skilled engineers
• Requires trained service-men • Exchange of cartridge by
laymen
• Requires significant CapEx
• Does not require significant
investment
CapEx
• Enables innovative revenue
model, from CapEx to OpEx
budgets
Requires expert know how
Complicates sales process
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Simplifies usage
Simplifies sales process
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C2V-200 micro GC
C2V’s unique MEMS micro fluidics integration platform enables
a world-class handheld chip-based GC instrument.
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Fast analysis: 10-30 seconds
Handheld sized
Easy exchangeable GC channel cartridges
Low power system (< 15 W typical)
Low costs (decrease per increasing volume)
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Excellent separation: N=10’000-25’000
Operating up to 180 oC
Fast T ramping: 100 oC / minute
ppm sensitivity with TCD
Less carrier/reference gas (operational 1 ml/min.)
Diagnostics on chip: flow/pressure
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C2V’s micro GC technology platform
Chip technology
• Using micro technology to create low cost GC
components (valves, injector, detector, column,
flow system, heating, flow diagnostics) with low
internal volume and low thermal mass
Integration of chips
• Using a fluidic multi chip module for
integration of these chip components in a fluidic
system with low dead volume connections
Cartridge
• The fluidic system module is assembled on an
exchangeable cartridge that contains the core
GC functionality
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GC Components: chips technology
Micro Injector:
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Micro TCD Detector:
Channel array chip
Membrane valves
Pneumatic actuation
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ppm sensitivity
ms response
Silicon columns:
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Fast heating
Integration on-chip
Capillary columns:
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Commercial available
Opt. geometry
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Fast GC Cartridge
C2V fast GC easy exchangeable cartridge (2” x 3.5” x 0.6”)
contains:
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Injector and sample loop
TCD detector
Column
Heating (2 zones)
C2V-200 micro GC module (3” x 4.5” x 1.2”)
contains:
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Easy exchangeable cartridge
Gas tight cartridge package
Read-out & control electronics
Pneumatics hardware
Connectors (gas & data & power)
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Fast GC Cartridges
Cartridge
ID
[mm]
Df
[µm]
Phase
Ratio
100% dimethylpolysiloxane
0.18
1
45.0
GCC1010
PLOT-U
0.25
8
7.81
GCC1020
WAS (PEG)
0.15
0.25
150
GCC1030
Molesieve
0.32
30
2.67
GCC1040
CarbonPLOT
0.32
3
26.7
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Column Type
Typical rentention time
15 seconds
Typical efficiency
10’000-15’000 plates
Typical flow rate
1-10 ml/minute
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Fast GC Cartridges
GCC1000 separation is almost entirely based on boiling points making this cartridge suitable for
a wide range of applications. Typical components: alcohols, esters, flavors and aromas, free
fatty acids, glycols, hydrocarbons, ketones, organic acids, oxygenates, PAHs, pesticides,
polymers, steroids, solvents, sulfur compounds.
GCC1010 elutes polar compounds as perfectly symmetrical peaks, allowing them to be
analyzed together with light hydrocarbons or permanent gases. Typical components:
halogenated compounds, hydrocarbons C1-C6, H2S, ketones, oxygenated hydrocarbons,
permanent gases/solvents.
GCC1020 provides optimal selectivity for many aqueous soluble compounds. Typical
components: BTEX, methanol, alcohols, aromatic hydrocarbons, esters, FAME, flavors and
aromas, free fatty acids, glycols, halogenated compounds, ketones, organic acids and solvents.
GCC1030 (molecular-sieve coated capillary column) is especially valuable when
separating permanent gases. Typical gases separated with the GCC1030 include:
He, H2, O2, CO, Ne, HD, N2, NO, Ar, D2, CH4, KrHT, X3, DT, CD4, Rn, T2.
GCC1040 separates N2, O2, CO, CO2 and C1-C2 hydrocarbons.
Typical gases separated by the GCC1040 include: He, Xe, CO, Ne,
CH4, CO2, O2/Ar, C2H6, N2, C2H4, Kr and C2H2
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C2V’s fast micro GC: data management
• C2V platform accommodates:
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Fieldbus
Profibus
Modbus
Wireless
• And interfaces with:
– RS 232
– USB
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Natural gas analysis (up to C5)
VB1 column:
→ 12 seconds @ 50 C
→ High separation quality
→ C2-C5, neo-pentane visible
Poraplot column:
→ 18 sec @ 80 C
→ High separation quality
→ N2, CH4, CO2, C2H6, C3H8
2.5
3,5
• Injection time 10 msec
• Column 50oC, chip 100oC
• Pactuation = 3 bar
• PHE=PNG = 1.5 bar
• column: VB1
• column: 5m/0.18mm/1mm
Ethane
Methane
Nitrogen
CO2
2
Propane
Column: Poraplot U 5m × 0.25mm
Carrier: Helium, 2 bar
Column T: 80 degC
Injection time: 10 ms
Methane
Nitrogen
3
2,5
Ethane
2
Signal
Signal
1.5
1,5
Carbon
dioxide
1
1
0,5
iso-Butane
n-Butane
0.5
Propane
iso-Pentane
neo-Pentane
n-Pentane
0
n-Hexane
-0,5
0
0
1
2
3
4
5
6
7
8
9
10
11
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13
0
5
Time (Sec)
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15
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Time (Sec)
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Natural gas analysis: C3-C6
4.8
4.5
4.2
Ethane
3.9
3.6
Natural gas measurement
3.3
Column: VB-1, 5m/0.18mm/1μm
S
Output signal
3
Nitrogen
CO2
Methane
2.7
C
O
a
m
a
v
r
p
r
e
i
n
l
e
e
l
r
t
g
e
m
o
o
a
s
p
p
:
:
H
e
r
μ
5
e
a
l
t
u
L
i
u
r
m
e
Propane
:
,
1
5
5
b
a
r
0
C
2.4
2.1
1.8
1.5
iso-Butane
1.2
n-Butane
0.9
neo-Pentane (500ppm)
0.6
iso-Pentane (500ppm)
0.3
n-Hexane (500ppm)
n-Pentane (500ppm)
0
-0.3
0
5
10
15
20
25
Time (sec)
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Natural gas: Temperature Program Run
Signal TCD1
1
peak# 2
Methane
0,9
Measurement date
Measurement time
Injector+detector T-setpoint (C)
Column T-setpoint (C)
Column ramp time (s)
Injection time (ms)
Measurement time (s)
peak# 5
iso-Butane
peak# 3
Ethane
0,8
Signal TCD1
peak# 4
Propane
0,7
peak# 6
n-Butane
1/4/2008
11:43 AM
120
40-180
40
100
45
output (V)
0,6
0,5
peak# 7
neo-Pentane
peak# 8
iso-Pentane
0,4
peak# 10
n-Hexane
peak# 11
n-Heptane
peak# 13
n-Nonane
peak# 12
n-Octane
peak# 14
Decane (11ppm)
0,3
peak# 9
n-Pentane
0,2
0,1
0
0
5
10
15
20
25
30
35
40
time (sec)
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BTEX headspace measurement
→ Very fast separation < 20 seconds (60oC)
→ Excellent separation quality
→ Zero peak tailing
→ Headspace injection
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BTEX headspace measurement
air
Column CP-Sil-8,
5m/0.2mm/0.33mm
Helium carrier, pressure 2bar
Oven temperature 80 oC
Injection time 200ms
Injected volume 5.5ml
benzene
0,8
0,6
Signal
toluene
0,4
ethylbenzene
m-xylene
p-xylene
o-xylene
0,2
0
2
4
6
8
10
12
14
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Time (Sec)
5m CP-Sil-8, 60oC, 2 bar, 200 ms injection time
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Reproducibility
Reproducibility test: > 100,000 runs to date
Showing results of 5,000 consecutive runs
Demonstrates: stability and reliability:
– Flow control
– Temperature control
– Injection repeatability
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Reproducibility
Retention time results: 5,000 consecutive runs
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Reproducibility
Peak height results: 5,000 consecutive runs
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C2V-200: fast Micro GC
Concept to Volume B.V.
C2V
For further information
or to test a fast, miniature GC for evaluation
please contact us at [email protected]
Dr. J. Elders, CEO
phone: +31 534 889 889
www.c2v.nl
Colosseum 20; 7521 PT Enschede
The Netherlands
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