Basic Electricity, Ionic Equilibrium, & Nernst and Goldman Equations

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Transcript Basic Electricity, Ionic Equilibrium, & Nernst and Goldman Equations

Ion Channels as pores…..
High capacitance of the PL bilayer is attributed
to the small length of the H-C chains (space between
the parallel plates).
Basic Electricity to Understand Biological Signals
The outer shell –
loss or gain of electrons
is the foundation of
Electronic Theory
What are the
analogous biological
membrane components
for a basic circuit?
Electron Theory
Positive to Negative
is the convention
attributed to Ben
Franklin, yet is not
reality
Ohm’s Law is most widely used physical law in
electrophysiology
Which is the biological circuit?
Why?
The Membrane
As a Capacitor
How does the capacitance
affect the voltage
response?
How do you calculate
capacitance?
How can capacitance
determine size of the
cell?
Potential difference driven by ion composition
and ATPase pumps
The Nernst Equation
The Goldman Equation
What Do Current
Voltage
Relationships
Tell us about
Selectivity and
Ion Channel
Properties?