Transcript Development and Aging

Development and Aging
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Fertilization
• Fertilization is the union of the sperm
and egg to form zygote.
Egg is surrounded by an outer matrix
called the zona of pellucida
Outside this matrix has a few layers of
follicular cells collectively called the
corona radiata
Sperm
• Flagellum allows the sperm to swim toward
the egg.
• The middle piece contains mitochondria.
• The head contains a nucleus capped by a
membrane-bound acrosome.
• Acrosome contains enzymes which digest a
portion of zona pellucida-PM.
Sperm
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Steps of Fertilization
Steps of fertilization:
1. Several sperm penetrate the corona
radiata
2. Acrosomal enzymes digests a portion
of the zona pellucida
3. The sperm binds to and fuses with the
egg’s plasma membrane
4. Sperm nucleus enters the egg
5. Sperm and egg nucleus will fuse.
What prevents more than one sperm
from entering?
• The egg’s plasma membrane changes to
prevent other sperm from binding. (pm
depolarizesfrom 265mV to 10mv)
• Vesicles within the egg release enzymes that
cause the zona pellucida to become
impenetrable and sperm cannot bind.
• To ensure proper development only one sperm
should enter the egg.
What are the main processes of
development?
• Cleavage – cells undergo division (2, 4, 8 etc) without the
embryo increasing in size
• Growth – cells undergo division as well as increase in size
• Morphogenesis – the embryo begins to take shape as cells
migrate
• Differentiation – when cells take on specific structure and
function (the nervous system is the first visible system)
What are the functions of the
extraembryonic membranes in humans?
• Chorion – fetal half of the placenta, the
organ that provides the embryo with
nourishment and gets rid of wastes
• Allantois – gives rise to the bladder and
the blood vessels of the umbilical cord
that carry blood to and from the fetus
• Yolk sac – contains many blood
vessels and where blood cells first
form (little yolk in humans)
• Amnion – contains amniotic fluid
that cushions and protects the
embryo
Extraembryonic membranes
What are the stages of development?
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Pre-embryonic development - 1st week of development after
fertilization
2.
Embryonic development – 2nd week after fertilization until
the end of the 2nd month
3.
Fetal development – the 3rd through the 9th months of
development
4.
Development after birth – stages of life including infancy,
childhood, adolescence and adulthood
1. Pre-embryonic development
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Cleavage – cell division that increases the number of
cells
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Morula – compact ball of embryonic cells
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Early blastocyst – inner cell mass that becomes the
embryo covered by a layer of cells that becomes the
chorion
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Implantation – embryo embeds into the uterus
around day 6
Early Development
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1. Pre-embryonic development: week 1
Embryonic Development-Week Two
• Pregnancy begins after implantation.
• Human chorionic gonadotropin (HCG) is
secreted maintaining the corpus luteum and
the endometrium.
• HCG is the basis for a pregnancy test.
• HCG maintains the corpus luteum in the
ovary.The high concentration of HCG
stimulates the corpus luteum to secretes
progesterone.
• This progesterone shuts down the
hypothalamus and anterior pituitary so
that no new follicles begin in the
ovary.
• The progesterone maintains the
endometrium(uterine lining) where the
embryo now resides.
• The inner cell mass detaches itself and
becomes the embryonic disk that will
go through gastrulation to become 3
primary germ layers (endoderm,
mesoderm and ectoderm)
2. Embryonic Development: week 2
Primary Germ Layers
• Ectoderm-outer layer-are epithelial
composed of tightly packed cells.
• Mesoderm-middle layer-loose connective
tissue.
• Endoderm-inner layer-are epithelial
composed of tightly packed cells.
Endoderm
• Becomes the Epithelial lining of:
• gastrointestinal tract (not oral cavity and
anal canal) and the epithelium of its glands.
• Urinary bladder, gallbladder and liver.
• Pharynx, auditory(eustachian)tube, tonsils,
larynx, trachea, bronchi, and lungs.
• Thyroid gland, parathyroid glands,
pancreas, and thymus
• Prostate and bulbourethral glands, vagina,
vestibule, urethra, and glands.
Medoserm
• All skeletal and cardiac muscle tissue
and most smooth muscle tissue.
• Cartilage, bone and other connective
tissues
• Blood, red bone marrow, and
lymphatic vessels.
• Endothelium of blood vessels and
lymphatic vessels.
• Dermis of skin
• Structures of the eye: sclera, cornea,
iris, ciliary body and choroid.
• Middle ear.
• Mesothelium of thoracic, abdominal
and pelvic cavities.
• Epithelium of kidneys and ureters.
• Epithelium of adrenal cortex.
• Epithelium of gonads and genital
ducts.
Ectoderm
• All nervous tissue.
• Epidermis of skin
• Hair follicles, arrector pili muscles,
nails, epithelium of skin glands
(sebaceous and sudoriferous) and
mammary glands.
• Lens, cornea, and internal eye muscles.
• Internal and external ear.
• Neuroepithelium of sense organs.
• Epithelium of oral cavity, nasal cavity,
nasal sinuses, salivary glands, and anal
canal.
• Epithelium of pineal gland, pituitary gland,
and adrenal medullae.
3 primary germ layers
2. Embryonic development: week 3
• Nervous system begins to develop
• The posterior neural tube will become the
spinal cord and brain
• Development of the heart begins
2. Embryonic development: weeks 4 & 5
• 4th week:
– Embryo is slightly larger than the height of the
print in your book
– Chorionic villi form
– Umbilical cord forms
– Limb buds form (later develop into legs and
arms)
– Hands and feet are apparent
• 5th week:
– Head enlarges
– Eyes, ears and nose become prominent
The embryo at week 5
2. Embryonic development: weeks 6-8
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Embryo begins to look like a human being
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Reflex actions occur
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Embryo is about
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All organ systems have been established
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38mm by the end of this period and weight about the
same as an aspirin tablet
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3. Fetal development: months 3 & 4
Hair develops
The head slows in growth so that the body size can
catch up
Cartilage begins to be replaced by bone
Able to distinguish female from male (month 3)
Can hear heartbeat with the stethoscope (month 4)
By the end of this period the fetus is about 6 inches
and about 6 ounces
3. Fetal development: months 5-7
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Fetal movement can
be felt by the mother
Fetus is in fetal
position
Eyelids are fully
open
Fetus size has
increased to 12
inches and 3 pounds
3. Fetal development: months 8 & 9
• Weight gain is about a pound per week
• Fetus rotates so that the head is pointed
towards the cervix
• At the end of fetal development the fetus
weighs about 7.5 pounds and 20.5 inches
long5 inches
2 Weeks
3 Weeks Old
5 Weeks
6 Weeks
Six Weeks
7 Weeks
8 Weeks
12 Weeks
14 Weeks
20 Weeks
26 Weeks
30 Weeks
32 Weeks
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Fetal circulation
Note: Fetal and maternal blood do not mix because exchange of materials between
the two occurs at the chorionic villi.
Development of the sex organs
• Sex of an individual is determined at
conception (XX is female and XY is
male)
• If the SRY (the sex determining region
on the Y chromosome) gene is present at
approximately 6 weeks then the embryo
develops into a male
• Anti-Mullerian hormone secreted by the
testes prevents the development of female
sex organs
• At 14 weeks primitive testes and ovaries
with gametes are already developing
• The development of the external organs is
dependent on the presence or absence of
dihydrotestosterone (DHT) produced by the
testes
Development of the sex organs
Abnormal development of the sex organs
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XY female syndrome - an individual develops
into a male because piece of the Y chromosome
containing the SRY gene is missing
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XX male syndrome – an individual develops into
a male because the same small piece of the Y
containing the SRY gene is present on an X
chromosome
Ambiguous sex determination
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Results from the absence of testosterone, AntiMullerian hormone and/or DHT
– Androgen insensitivity syndrome: all hormones are made
but testosterone receptors on cells are ineffective thus the
individual has testes that do not descend and outwardly
appear to be female
– Male pseudo-hermaphroditism: an individual appears
female until puberty when anti-Mullerian hormone is
produced but the testes never produce testosterone or
DTH
What are the good and bad changes in the
mother’s body?
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Nausea and vomiting are common symptoms early on
(morning sickness)
Some mothers report an overall increase in energy levels and
sense of well-being
Acid reflux and constipation are common problems
There is an increase in vital capacity
Edema and varicose veins can result
Incontinence is not uncommon
The placenta produces peptide hormones that makes cells
resistant to insulin so diabetes can result
Stretch marks are common
Melanocyte activity increases in some areas
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Birth
True labor is characterized by uterine contraction that occur every 15-20
minutes and last for at least 40 seconds
• 3 stages:
– 1st:
• effacement occurs in which the cervical canal
slowly disappears and the babies head acts as a
wedge to cause cervical dilation
– 2nd:
• uterine contractions every 1-2 minutes lasting
for ~1 minute each
• an incision is made to the opening to help the
baby as its head reaches the exterior;
• once the baby is born the umbilical cord is cut
and tied
3rd:
• The afterbirth is delivered usually
about 15 minutes after the birth of the
baby
17.4 Pregnancy and birth
Birth
Health focus: preventing birth defects
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Get physical exams by a trained doctor
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Have good health habits: proper nutrition and adequate sleep and exercise
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Avoid smoking, alcohol and drug abuse
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Avoid having x-rays
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Avoid certain medications and supplements
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Avoid sexually transmitted diseases or know if you have one
Aging
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Stages of life: infancy, childhood, adolescence and
adulthood
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3 hypotheses of aging:
– Genetic origin: suggests mitochondrial activity is
involved with aging
– Whole body processes – suggests aging may be a result
from body systems or type of tissue (such as the loss of
hormonal activities or cross-linking in support tissues)
– Extrinsic factors: suggests that aging may be due to years
of poor health habits such as a poor diet and lack of
exercise
What are the effects of age on body systems?
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Skin becomes thinner, less elastic and dry
Less adipose in the skin so one feels colder more easily
Decrease in melanocytes leading to gray hair while some of the
remaining cells are larger leaving “age spots” (dark spots on the skin)
Heart shrinks and arteries become more rigid
Reaction time slows and senses are muted
Lens in the eye loses ability to accommodate
Blood pressure usually increases
Bone density declines
Muscle mass decreases
Weight gain results from a decrease in metabolism and an increase in
inactivity
Females undergo menopause and males andropause
Think about how you might prevent aging
Note: although many changes occur in the body as we age some of them can be
tempered or even reversed by understanding what extrinsic factors can be controlled
to decrease these changes