Transcript - Chemical and Molecular Toxicology

GLORY LILY
Jann Andre H. Padua
Rhowell N. Tiozon Jr.
III - BSCT
TAXONOMY
 Kingdom
: Plantae
 Phylum : Magnoliophyta
 Class : Liliopsida
 Order : Liliales
 Family : Liliaceae
 Genus : Gloriosa
 Species superba
VERNACULAR NAMES
 Kalihari
in Hindi
 Kal-lavi in Marathi
 Manthori khizangu in Malayalam
 Kazhappai kizhangu in Tamil
 Flame Lily, Glory Lily, Tiger Claw in English
BOTANY AND ORIGIN
 Gloriosa is
a native of tropical Asia and
Africa. The genus derives its name from
the Latin word gloriosus, referring to the
flowers. It is found growing throughout
tropical India, from the North -West
Himalayas to Assam and the Deccan
peninsula.
BOTANY AND ORIGIN
It
is also found growing in Madagascar,
Sri Lanka, Indo-China, Bangladesh,
Malaysia Myanmar, Indonesia and on
the adjacent island.
BOTANICAL FEATURE
It
is an herbaceous, climbing perennial,
growing between 3.5 to 6m in length,
but usually trained at 1.5m above
ground level.
TOXICOLOGICAL PROFILE
GLORIOSA
SUPERBA
GLORIOSA SUPERBA
GLORIOSA SUPERBA
CHEMICAL CONSTITUENTS
 Cornigerine
3-demethyl-N-formyl-N-deacetyl-βlumicolchicine
 3-demethyl-g-lumicolchicine
 3-demethyl colchicines
 colchicocide
 gloriosine

CHEMICAL CONSTITUENTS
 tannins
 superbine
β
-sitosterol
 Glucoside
 a long chain fatty acid
 β and g-lumiccolchicines
CHEMICAL CONSTITUENTS
 Luteolin
colchicines
 N-formylde
 acetylcolchicines
 glucosides of 3-demethylcolchicine

CHEMICALS ON EACH PART
COLCHICINE and GLORIOSINE
They
are pale yellow to greenish
yellow alkaloids.
They are considered as
phytochemicals which is
concentrated on the tubers.
COLCHICINE
GLORIOSINE
MODE OF ACTION
 Colchicine
has an antimitotic effect
– It stops cell division by disrupting the
spindle apparatus during the metaphase
– Cells with rapid turnover are affected
(bone marrow, intestinal epithelium, hairproducing cells -> hair loss)
– It can alter neuromuscular function
CLINICAL FEATURES OF POISONING
 Initial
symptoms develop within 6-12 hours
of ingestion
- pain, numbness, itching and tingling around
the mouth and throat with thirst
- nausea, intense vomiting
- abdominal pain, severe diarrhoea with blood
and mucus
CLINICAL FEATURES OF POISONING
These
lead to
– electrolyte imbalance
- dehydration
- hypovolaemic shock manifested
- hypotension
- tachycardia
CLINICAL FEATURES OF POISONING
 After
24 hours patients develop
– Muscle weakness, myoglobinuria,
bronchial
constriction,
leucopenia,
thrombocytopenia, clotting defects with
bleeding,
polyneuropathy
cardiac
arrhythmias, hepatic insufficiency, acute
renal failure.
CLINICAL FEATURES OF POISONING
In
severe cases, there may be:
– Respiratory depression,
confusion, delirium, convulsions,
coma
 Death occurs due to shock or
respiratory failure
DIAGNOSIS
Toxicological
analysis
Biomedical analysis
blood gas analysis
 hematological analysis
TREATMENT
hospitalize the
patient immediately
induce vomiting (ipecac) / gastric
lavage
give repeated activated charcoal
supportive care eg IV fluid, assisted
ventilation may be needed
ETHNO-MEDICAL IMPORTANCE
According
to ayurveda, tuber is
pungent, bitter, acrid, heating,
anthemirtic,
laxative,
alexiteric,
abortifacient and useful in ulcers,
gonorrhea,
leprosy,
piles,
inflammations,
abdominal
pains,
itching and thirst.
ETHNO-MEDICAL IMPORTANCE
Tubers
are also used as antifertility
purpose.
The root paste is used for curing
gout, stomach ache, abortion
purpose in intermittent fever,
wounds.
ETHNO-MEDICAL IMPORTANCE
It
can be administered to a delivered
mother along with spirituous drink to
give relieve to her postnatal complaints
and also if its root paste smeared over
the palms and feet of a pregnant
woman, delivery of child becomes
easier.
ETHNO-MEDICAL IMPORTANCE
 Leaves
of Glory lily have more
medicinal qualities, namely for
curing asthma, its juice is effective
against lice and also against many
skin disorders and treatment of
various respiratory disorders.
PROMISING BENEFIT
Analgesic
and anti-inflammatory
potential = gout and rheumatism
Antimicrobial properties –
• antibacterial and antifungal potential.
• Candida albicans and Candida
glaberata.
PROMISING BENEFIT
Larvicidal
Potential= larvae of
malaria vector and cattle tick.
Antithrombotic/Anticoagulent
potential = thrombin induced clot
Antitumor potential= cytogenic for
P-388 cell line
PROMISING BENEFIT
Enzyme
•
•
•
•
inhibition potential
Lipoxygenase
acetylcholinesterase,
butyrylcholinesterase
ureas.
Treatment
of snake bite (neutralize)
THANK YOU
“Life is like a Pandora’s Box. There may be
too many harm it may done to us but it
depends on us on how we are going to
make this harm for our advantage”
- Anonymous