Transcript objective
Anti-rheumatics Colchicum DEPARTMENT OF TECHNICAL EDUCATION ANDHRA PRADESH Name Designation Branch Institute Year Subject Subject Code Topic Sub-Topic Duration Teaching Aids : R.D.L.P.Christian : Lecturer in pharmacy : Pharmacy : GPW, Srikakulam(088) : I year : Pharmacognosy : PH-103 : Anti-rheumatics : Colchicum : 50 min. : PPT, Photographs Recap In the last class we learnt about • The monograph of the Anti-rheumatic drug GUGGUL • Guggul contains oleo-gum resin containing steroids and essential oils • Can be used for variety of purposes apart from antirheumatic activity OBJECTIVES On completion of this period you would be able to learn about The monograph of the Anti-rheumatic drug COLCHICUM Colchicum autumnale Fig.42.1 Colchicum plant COLCHICUM Syn: Meadow saffron seed, Wild saffron Autumn crocus • Biological Source : Dried ripe seeds & corms of Colchicum autumnale Colchicum luteum • Family : Liliaceae • Geographical Source : Many European countries, In India found in West Himalayas & Kashmir region Fig.42.2 Colchicum flower Cultivation, Collection & Preparation • Repeats life cycle with the corm which is present as a swollen underground stem • Towards the end of summer the fully grown corm develops the daughter corms in the axile of scale leaves • The daughter corms develop parasitically on the parent corm Fig.42.3 • The parent corm withers and the daughter corms develop into new plants Collection & Preparation In Europe and Jammu & Kashmir it is propagated by seeds Sowing of seeds at an altitude of 1000-3000m Seedilings transplanted to open fields at a distance of 1m Plants (bear capsular fruits) Fruits collected before dehiscence & dark seeds are separated, processed and graded Corms are isolated Corms are sliced transversely and dried below 650 C MORPHOLOGICAL CHARACTERS SEEDS • Size : 2-3mm in diameter • Taste : Bitter and acrid • Odour : No odour • Very hard and have reddishbrown testa • Have a projection at the hilum and develops a strophiole (outgrowth of testa) Fig.42.4 Colchicum flower MORPHOLOGICAL CHARACTERS CORMS: • Size : 2-3 cm diameter • Shape : Reniform and ovate with short fracture • Taste : Bitter taste • Odour : No odour Fig.42.5 Dried Colchicum CHEMICAL CONSTITUENTS • Contains Amino alkaloids : Colchicine, Cholchicein, Demecolcine, Colchicoresine • The alkaloids containTropolone or Cycloheptatrien-olone ring structure • Seeds contain 0.8% Colchicine and corms contain 0.6% Colchicine • On exposure to UV light Colchicine changes to Lumicolchicine CHEMICAL TESTS 1. Drug + 60-70% H2SO4 or HCl Yellow colour (due to Colchicine) 2. Alc. Soln. of Colchicine + FeCl3 Red colour USES • Specific for the treatment of Gout and Rheumatism • Demecolcine is effective against epidermal cancer and Myeloid leukaemia • Colchicine is used to induce Polyploidy • Used in Horticulture and cultivation of medicinal plants SUMMARY In this class we learnt about • The Anti-rheumatic plant drug COLCHICUM • The important constituent of Colchicum is the Amino alkaloid COLCHICINE QUIZ 1. The plant part that is useful in colchicum is a) b) c) d) Seed Corm Both None of the above QUIZ 2.The important chemical constituents of colchicum a) Amino alkaloids b) Quinoline alkaloids c) Indole alkaloids d) None of the above FREQUENTLY ASKED QUESTIONS 1. What are Anti-rheumatics? Write the Botanical source and Morphology of Colchicum 2. Write the Chemical constituents and uses of Colchicum 3. Write the Botanical source and Uses of Colchicum