Transcript Slide 1

Keratometric Changes in
Noninflammatory Corneal Ectasic
Diseases After Intraocular Pressure
Reduction
Authors has no financial interest.
Renata T Kashiwabuchi, Camila Gadelha,
Wilson de Freitas, Carlos Arce, Mauro Campos
Federal University of Sao Paulo, Paulista School of Medicine –
Sao Paulo, Brasil
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Purpose: To assess possible keratometric
changes after intra-ocular pressure
reduction and describe any change
observed.
Methods
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Ten patients: 9 bilateral keratoconus and 1 corneal ectasia after
refractive procedure.
All patients were submitted to the follow exams before and after
intra-ocular pressure reduction:
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Corneal Analysis System EyeSy (EyeSys Laboratories Incorporation,
Houston, Texas, USA),
Pentacam (Oculus, Wetzlar, Germany),
Corneo-Gage Plus (Sonogage, Cleveland, OH),
Galilei (Zymer, SMT Swiss Microtechnology AG, Port, Switzerland)
Ocular Respose Analyser (ORA; Reichert Ophthalmic Instruments, Depew,
NY),
Intra-ocular pressure was measured by Goldman applanation tonometer in
90 and 180 axes by examiner 1 as well as all exams.
Methods
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For each patient one eye was assigned
randomly to receive hypotensive drugs.
Instructions about the drops were given to
the patients by examiner 2.
Examiner 1 has no access to details of
random process.
Results (table)
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Significant differences were observed in the follow
data (hypotensive group):
PIO (Goldman) = 5.45 ± 2.3 mmHg (p=0.00),
Pentacan
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Anterior Chamber Depth= 3.5 ± 0.3 µm (p = 0.04)
Anterior Chamber Volume= 218 ± 42.95 mm3 (p= 0.004),
ORA data:
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IOPcc= 8.1 ± 3.1 mmHg (p= 0.00),
IOPg= 4.75 ± 2.1mmHg (p= 0.00)
CRF= 6.0 ± 0.4 (p= 0.01).
Results (abbreviation)
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IOP (Goldman)= Intra ocular pressure assessed by Goldman
Tonometry
Km =mean simulated K power
P= Pentacan
Km post = posterior corneal power
ACV = Anterior Chamber Volume
ACD = Anterior Chamber Depth
G = Galilei
IOPcc = Corneal Compensated Intra Ocular Pressure
IOPg = Goldman Compensated Intra Ocular Pressure
CRF = Corneal Resistance Factor
CH = Corneal Histeresis
Before
After
PIO (Goldman)
11.9 ± 2.3 mmHg
5.4 ± 2.3 mmHg
Km (EyeSys)
Km= 47.6 ± 6.6
47.4 ± 6.3
Km (P)
42.9 ± 14.8
46.8 ± 4.8
Km post (P)
-5.5 ± 4.6
-6.9 ± 0.8
ACV
229.9 ± 41.5 mm3
218.9 ± 42.9 mm3
ACD
46.84 ± 4.8 µm
46.84 ± 4.8 µm
Km (G)
49.9 ± 7.4
49.7 ± 7.3
Km post (G)
-7.5 ± 1.2
-7.4 ± 1.2
IOPcc
15.2 ± 5.8 mmHg
8.1 ± 3.1mmHg
IOPg
12.5 ± 3.6 mmHg
4.7 ± 2.1 mmHg
CRF
8.1 ± 1.0 mmHg
6.0± 0.4 mmHg
CH
8.7 ± 2.5 mmHg
9.1 ± 1.2 mmHg
Data from hypotensive group
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Conclusion: Even though a significant intraocular pressure reduction no keratometry
changes were observed in no device used.