Transcript Iodine to the Rescue

Iodine & Iodine
Testing to the Rescue
Jackie Harvey
WHY TEST for IODINE
Insufficiency ?
We are becoming deficient !!
• low iodine in the soil
• salt free diets
• excess Bromine, Fluorine and
Chlorine in our world are competing
with Iodine absorption
• many with low Thyroid function and
on synthroid meds
“Iodine
Why You Need It, Why You Can’t Live Without
It.” David Brownstein MD, 2nd edition, 2006
• Recent Study…Of 3000 patients
(USA) tested
• 90% were found to be
deficient.
Negative THYROID
REPLACEMENT Result
“Approximately 600,000 elderly
individuals have iatrogenic
hyperthyroidism from thyroid
hormone overdose, putting them at
risk for atrial fibrillation and
osteoporosis.”
Cooper DS, Ridqway EC. Thought on prevention of thyroid disease in the United States.
Thyroid 2002 Oct;12(10):925-9
THYROID HORMONE
REPLACEMENT
• Depletes the body’s stores of iodine
– Shown by fluorescent scan
• Increased risk of cancer with long-term
use
• Recommend all thyroid medications be
used in conjunction with iodine!
SYMPTOMS of LOW Thyroid
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Are you often fatigued?
Do you get frequent infections?
Do you have multiple allergies?
Are you always cold? Or cold hands and feet?
Does your hair fall out?
Do you have difficulty losing weight?
Do you suffer from headaches?
Are you constipated?
Do you have PMS?
Do you have a brain fog?
IODINE IS DEPLETED BY:
• FLUORIDE
• CHLORINE
• BROMINE
• THYROID HORMONE
• PESTICIDES
Iodine was considered so
ESSENTIAL …
• That it was added to Bread as a
supplement (until twenty years ago)
• Now the toxin: Bromine is added
instead
– Which interferes with iodine uptakes and
ultimately depletes the body of iodine
Iodine
• Discovered by Frenchman;
Bernard Courtois in 1804
• The name originates from
the greek word “iodes”
which means violet.
Thyroid Hormone Pathway
Pituitary (Brain)
↓
TSH
↓
Thyroid
↓
T4 (inactive)
↓
T3 (active)
Thyroid Hormone Pathway
Pituitary (Brain)
↓
TSH
↓
Thyroid
↓
T4 (inactive)
↓
IODINE
T3 (active)
IODINE
Sufficient levels of Iodide/Iodine are required
for adequate thyroid hormone production.
Iodine insufficiency effects:
•an enlarged thyroid gland (goiter)
•fatigue
•reduced cognition
•constipation
•low libido
•slow pulse
• brittle hair/nails and hair loss
•fibrocystic breasts
• (Similar to symptoms of low Thyroid!!)
IODINE and our Breasts
Evidence-based research supports the possibility that
breast cancer may be an iodine deficiency disease.
IODINE accomplishes the following:
1. Desensitizes estrogen receptors in the breast.
2. Reduces estrogen production in overactive ovaries.
3. Reduces fibrocystic breast disease (FDB) which
often precedes breast cancer
4. Causes more cell death than the chemo drug
Fluorouracil.
Iodine Physiology
• Is detected in every organ and tissue in
the body … Especially high levels are
found in the:
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Thyroid
Liver
Lung
Heart
Adrenals
– And highest concentrations in fat and
muscle tissue
– Breast tissue
– Sweat glands
– Stomach tissue
Summary of established conditions
responsive to orthoiodosupplementation
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Fibrocystic breasts
Polycystic Ovarian Syndrome
Hypothyroid
Hyperthyroid
Cognitive dysfunction (Brain fog)
Diabetes
Arrhythmias (supra-ventricular, e.g. atrial
fib.)
• Breast Cancer prevention
Flechas JD. Orthoiodosupplementation in a Primary Care Practice. The Original Internist, 2005; 12(2):89-96
Summary of possible conditions
responsive to orthoiodosupplementation
• Hypertension
• Cardiovascular Disease
• Brain Fog
• Breast Cancer
• Liver Dysfunction
Iodine Testing
• Tincture of Iodine/skin test;
Not precise-but lay-person can perform at
home.
– Paint tincture on a 2 inch spot on arm-if it disappears in
less than eight hours…You are severely deficient in iodine.
If it disappears in 24 hours you also need iodine…if it stays
on your arm and begins to slowly fade in color after a full
24 hours, you have reached iodine sufficiency.
• Urine Iodine Loading
– Collect baseline “spot urine. Then take 50 mg of iodine
and collect all urine in next 24 hour period. If you secrete
out 90% or more iodine you have iodine sufficiency. If the
percentage is less than 90% you are iodine deficient
URINE TESTING
This is a 2 part test:
• The SPOT test is the first urine void of the morning.
From this first void, the level of iodine is measured in the
urine, to establish a baseline.
• The LOADING test is a measurement of whole body
sufficiency for iodine. 50mg of Iodine/Iodide supplement
(Iodoral®) is provided with the kit and is ingested (after
the spot test) and a 24 hour collection is started at the
next void. From the 50mg ingested for the loading test,
the LOADING EXCRETION results will show how many
milligrams of Iodide are excreted, and what percentage
of the 50mg ingested, is excreted.
TEST KITS
• Kit includes all collection materials and the
means to ship the specimen to the lab.
• Full collection instructions are included.
• Results are provided within 10-15 days from the
time the test was received at the lab.
• A review can be requested from our Help For
Hormones Team members. Iodine Test kits are
available from Help for Hormones website.
• TEAM members may stock test kits if they wish.
Iodine’s Widespread Use
From 1900-1960’s nearly every
physician in the United States used
Iodine (Lugol’s solution) supplements
in their practice for both hypothyroid
and hyperthyroid conditions… all with
excellent results.
Why Lugols (formulation) is
effective.
• Dr Abrahams notes that the research
shows that the thyroid gland prefers
Iodide
• The other organs (breasts etc.) prefer
elemental Iodine.
*both forms are present in equal parts in
Lugols solution
Forms of Iodine—inorganic,
organic
• Liquid (Lugol’s solution, SSKI)
–Tastes bad, can upset your
stomach and will stain
clothing
• Coated Tablets over come
these problems - Iodoral
Lugols solution
• 10% iodine(I2), 10% potassium iodide (KI) in
80% distilled water with a total iodine content
of 130mg/ml
• was OTC Until AUGUST/2007, when the DEA
began regulation of Lugol’s and any other
iodine solutions containing greater than 2.2%
iodine.
• Also known as IKI (Iodine Potassium Iodide),
Strong solution and Aqueous Iodine Solution
BP.
Therapeutic Protocol after testing
for iodine deficiency
50 mg/day PO for ninety days
RE: TEST
12.5 mg/day PO maintenance
With 3000mg per day Vit C
(see Our expanded protocol)
Therapeutic Protocol after testing
for iodine deficiency
Possible DETOX symptoms
(spilling Bromine, chlorine and Hg)
Feeling funky, e.g.
Headaches
Malaise
Loss of appetite
Sleep Difficulty
*Reduce dose for two weeks and retry.
Laboratory Response to
Orthoiodosupplementation
• TSH generally goes down. TSH may go up
and likely represents the bodies attempt to
make more sodium iodine symporters (iodine
channels), aka, NIS
• Free T4 usually goes down
• Free T3 usually goes down
• Majority of patients lose fat and gain muscle
mass
Flechas JD. Orthoiodosupplementation in a Primary Care Practice. The Original Internist, 2005; 12(2):89-96
FOOD
Salt (iodized)
Cod
Shrimp
Fish sticks
Tuna, in oil
Milk (cow’s)
Egg, boiled
Navy beans
Potato c peel
Turkey breast
Seaweed
SERVING
1 gram
3 ounces
3 ounces
2 fish sticks
3 ounces
1 cup (8 oz)
1 large
½ cup
1 medium
3 ounces
¼ ounce, dried
Iodine (mcg)
77
99
35
35
17
56
12
32
60
34
>4,500
Allergic Reactions
Executive Summary
• Anaphylactoid reactions to RCM
(Radiocontrast Material) should not be
considered evidence of KI allergy.
• Allergic contact dermatitis from iodinecontaining antibacterial preparations should
not be considered evidence of IgE antibody
mediated KI allergy or sensitivity.
Academy Position Statement: The Risk of Severe Allergic Reactions from the Use of Potassium Iodide for Radiation
Emergencies. American Academy of Allergy Asthma and Immunonology. February 24, 2004.
Allergic Reactions
Executive Summary (cont’d)
• IgE antibody mediated allergy to
seafood should not be considered
evidence of KI allergy or sensitivity.
• Physicians should ensure that persons
are not allergic to inactive
ingredients/components of the KI
formulation prescribed.
Academy Position Statement: The Risk of Severe Allergic Reactions from the Use of Potassium Iodide
for Radiation Emergencies. American Academy of Allergy Asthma and Immunonology. February
24, 2004.
Allergic Reactions
OBSERVATIONS ON IODIDE
SENSITIVITY
Peacock LB and Davison HM. Ann Allergy. 1957 Mar-Apr;15(2):158-164
• Retrospective study of 502 asthmatics.
• 81 reactions to KI reported (16.1%); 68
discontinued therapy (13.5%); 13
continued at a lower dose (2.6%).
• Dose ranges (gms): Single 0.53 to 1.87;
Daily 1.6 to 5.6. Note: KI
supplementation is typically 0.012.5 to
0.050 gm/day
Allergic Reactions
OBSERVATIONS ON IODIDE SENSITIVITY
Peacock LB and Davison HM. Ann Allergy. 1957 Mar-Apr;15(2):158-164
• Rash (papular) 42 (51%), Nausea 10 (12%),
Metallic taste 7 (8.6%), Salivary gland edema
7 (8.6%), Goiter 5 (6%), Nasal sxs 5 (6%),
Increased asthma 3 (4%)
• Hoarseness, diarrhea, throat edema and sore
throat: 2 ea (2%)
• Insomnia, thinning hair, bladder/kidney sxs,
headache, chills fever, vomiting,
nervousness, aching jaw, herpes and
burning in mouth and nose: 1 ea (1%) .
Allergic Reactions
OBSERVATIONS ON IODIDE
SENSITIVITY
Peacock LB and Davison HM. Ann Allergy. 1957 Mar-Apr;15(2):158-164
No Anaphylactic Reactions
Reported!
Iodine allergies to routine dosages are
essentially a Myth!
Thyroidectomy
• Even patients with no thyroid
gland benefited from iodine
therapy: