Transcript Slide 1

Section2
Clinical Approaches of MSCs
Gene
&
Cell
therapy
Tissue engineering
Encapsulated cell biodelivery
Potential uses
Cell based therapies:
 Regenerative therapy to treat Parkinson’s,
Alzheimer’s, spinal cord injury, stroke, severe
burns, heart disease, diabetes, osteoarthritis, and
rheumatoid arthritis
 Stem cells in gene therapy

Stem cells as vehicles after they have been genetically
manipulated
 Stem
cells in cancer
Traumatic brain injury
according to the World Health Organization,
traumatic brain injury (TBI) will surpass many diseases
as the major cause of death and disability .It is estimated
that 10 million people are affected
annually by TBI, with the highest incidence among
persons 15 to 24 years of age and 75 years and older.
Since TBI may result in lifelong impairment of an
individual's physical, cognitive, and psychosocial
functioning, and given the absence of a cure, TBI is a
disorder of major public health significance.
Current therapies in neurotrauma aim particularly to
prevent brain edema, raised intracranial pressure,
ischemic damage and in bleedings.
most of the
mentioned therapies are associated with problems and
are thought as a complementation of the existing
therapies. Stem cell therapy aims not only for receiving
brain tissue and functions but also for restoring of both.
So, stem cell therapies may possess the most effective
potential for neuronal and functional recovery.
Stages of fracture healing
 Inflammation
 Repair
 Remodeling
strategies for cell therapy
in neurotrauma
“cell replacement”
“mini – pumps"
pharmacologic manipulation
and / or gene therapy
• release of trophic factors, enzymes and
neurotransmitters
• buffering toxic molecules
• blocking of endogenous repair-inhibitory factors
• expressing extracellular matrix molecules
• stabilize brain tissue and promote remyelination
• providing favorable cell-cell communication
neuronal and functional recovery
Clinical trials
Phase 1:
-proof of safety
Phase 2:
-proof of efficacy
Phase 3:
-proof of clinical usability
Thanks for your
attention
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