Transcript Probiotics - jefechi.com

Probiotics
There are up to 400 different bacterial species in the colon and the vast
majority (99.9%) are strict anaerobes.
Genus
feces
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Non-sporing anaerobes
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Sporing anaerobes
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Lactobacillus spp.
Streptococcus spp.
Enterococci
Facultative organisms
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5-9
Bacillus spp.
Microaerophiles
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Clostridium spp.
10- 11
10- 11
9 - 11
9 - 11
5-8
Sporing aerobes
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Bacteriodes spp.
Bifidobacterium spp.
Eubacterium spp.
Propionibacterium spp.
Veillonella spp.
Log10 bacteria per gram
Coliforms
other Enterobacteria
7-9
7-9
5-7
7-9
5-9
http://www.gla.ac.uk/departments/humannutrition/students/resources/meden/Infection.pdf
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For context – Total Cells
 Them ~ 100,000 billion.
 You ~ 10,000 billion.
Microbiotic therapy
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Indications for use:
Crohn's disease, ulcerative colitis, intestinal
disturbances, gas and bloating, constipation,
diarrhea, dysbiosis, yeast-overgrowth, parasites,
irritable bowel syndrome, autoimmune
conditions, MS, lupus, AIDS, rheumatoid
arthritis, during and post antibiotic use, post
chemotherapy, post radiation, food allergies,
chronic fatigue syndrome and pharmaceutical
drug use.
The Big players
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Lactobacillus acidophilus
Lactobacillus acidophilus is found primarily in the small intestine
It produces natural antibiotics (lactocidin & acidophilin), thereby, increasing your immune system's resistance against bad bacteria
and fungus i.e. Candida albicans, Salmonella, E. coli, and Staphylococcus aureus
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It implants itself on the intestinal walls, the lining of the vagina, cervix and urethra
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For years it was assumed that Lactobacillus acidophilus was the most beneficial form of the good bacteria. However, recent
research has revealed that Lactobacillus rhamnosus is just as important for good bacteria supplementation.
Bifidobacterium bifidum
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Bifidobacterium bifidum reside mainly in the mucous membrane of the large intestine and vaginal tract
Digests lactose
Produces the most beneficial form of lactic acid and acetic acid
Ferments indigestible fibers which produces more energy
Synthesizes some vitamins and aids mineral absorption (calcium, magnesium and zinc)
Inhibits the growth of Salmonella sp., Listeria, Shigella, E. coli and Clostridium per fringens by crowding out these bad
bacteria and eating their nutrients
Fights the bad bacteria in your body by lowering the intestinal pH through production of fatty acids
Absorbs large quantities of ferrous ions, inhibiting the growth of bad bacteria
Aids constipation and diarrhea with lactic acid production
Lactobacillus rhamnosus
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Lactobacillus rhamnosus is a healthier species of good bacteria and colonizes in your gut mucosa
Relieves hypersensitivity reactions and intestinal inflamation in individuals with exzema and food allergies
Excellent stability over a wide range of temperatures and pH levels
Inhibits the growth of bad bacteria
Enhances the immune system's resistance
Demonstrated antitumor activity
Prevents food allergies caused by a "leaky gut" condition
More Players
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Lactobacillus plantarum
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Bifidobacterium infantis
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Produces lactic acid
Synthesizes Vitamins D & K
Streptococcus thermophilus
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Close relative to Lactobacillus acidophilus
Secretes "peptidoglycan" a recognized substance that supports the body's natural defenses
Lactobacillus brevis
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Used in fermenting natural yogurt
Produces lactic acid
Provides a great environment for Lactobacilli and Bifidobacterium to grow
Lactobacillus casei
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Destroys harmful bacteria
Aids in bowel disorders
Lactobacillus bulgaricus
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Present in the intestines of infants and adults
Present in the vaginal tract
Lactobacillus salivarius
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Helps produce lactolin, a natural antibiotic
Synthesizes the amino acid, L-lysine, which is anti-viral
Breaks down milk products by producing lactase (helps individuals that are lactose intolerant)
Destroys Pseudomonas sp., E. coli, Staphylococcus aureus, Salmonella sp., and Shigella
Produces Methanol acetone, a potent anti-pathogenic agent
Undesirable types such as E. coli, Klebsiella, Clostridium and Candida albicans.
Prebiotics?
Fructo-oligo-saccharides
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Fructo-Oligo-Saccharides (FOS) is a naturally-occurring water-soluble fiber
from fruit and vegetables which feeds the friendly intestinal bacteria.
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FOS generaly ensure rapid establishment of the Lactobacilli in the upper
small intestine and bifido bacteria in the lower small intestine.
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Some, research suggests that there may be health benefits of
supplementing the diet with between 5 and l0g of FOS,
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It, HMF product, also provides naturally-occurring beta-carotene from the
whole freeze-dried apricot. The apricot is used for its soothing effect on
the intestinal walls (and great flavor in the powders).
Townsend letter article
http://www.findarticles.com/p/articles/mi_m0ISW/is_2003_June/ai_10
2372155
Inulin
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Inulin
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Inulin is a multi-chain fructooligosaccharide derived
from chicory root
It is a chain of fructose (a carbohydrate) that is not
digestible by your body, therefore, it can pass
through the body into the large intestine where it can
feed your good bacteria cells
Some, research has suggested that Inulin (9 chain links) is more
effective than FOS (3 to 4 chain links) at feeding your body's good
bacteria. Also, Inulin may be better tolerated by humans and bad
bacteria are less likely to feed on it.
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Human Micro Flora
HMF
Genestra Brands
Form Seroyal
New! Oct 2004, all HMF probiotics contain a substantial increase in potency (double) and
no price increase.
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HMF Replete contains…
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Fructo-oligosaccharides
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Lactobacillus acidophilus
Lactobacillus salivarius
Bifidobacterium bifidum
Bifidobacterium lactis
high concentrations ensure
rapid establishment and
dominance of probiotic
cultures in the GI
Indicated during and following
antibiotic therapy and
chemotherapy.
Genestra Brands
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HMF Replete new and improved formula!
Each sachet (20 g) of HMF Replete
supplies:
Lactobacillus acidophilus .........75 billion CFU
Bifidobacterium Bifidum .......12.5 billion CFU
Bifidobacterium lactis ........... 12.5 billion CFU
Lactobacillus salivarius ........... 30 billion CFU
Fructo-oligosaccharides .................... 10 g
May contain up to .................. 170 billion CFU
HMF Recommendations
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Intensive Phase
Take 1 packet daily (½ packet twice
daily) after meals, mixed in water or
off the spoon for 7-14 days.
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Clinical Considerations
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During and Post-antibiotic therapy
Acute intestinal upset
Candidiasis
Digestive disturbances (bloating, gas)
Parasitic infections
Chronic Fatigue Syndrome
Bowel problems (constipation,
diarrhea, IBS)
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Intermediate Phase
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Take ½ packet daily after meals mixed
in water or off the spoon.
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Clinical Considerations
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General illness
Stressful life style
Parasitic infections
Digestive problems (bloating, gas)
Constipation
Excessive alcohol consumption
Bowel problems (constipation,
diarrhea, IBS)
Chronic Fatigue Syndrome
Candidiasis
Genestra Brands
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HMF Replete Features:
HMF replete is the strongest HMF probiotic
prolonged stability allowing for storage up to 3 months
at room temperature
resistant to stomach acidity and bile acids
scientific evidence with clinical data to confirm efficacy
laboratory tested to confirm potency and purity
exceptional ability to attach to intestinal cells due to
human sourced lactobacilli and bifidobacteria
Genestra Brands
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Super Powder is a high-level maintenance
probiotic formula.
Indicated for individuals who use antibiotics,
oral contraceptives, steroids and hormonal
replacement therapy, and for extreme fatigue,
allergies, yeast overgrowth, stress,
hypercholesterolemia and indigestion.
HMF Super Powder is highly recommended
for ongoing maintenance in individuals who
are immuno-compromised.
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Ideal for children and adults who dislike or
have difficulty swallowing capsules.
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* Powder is ideal for vegans
Genestra Brands
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Each 1/4 teaspoon (1 gram) of HMF Super
Powder supplies:
Lactobacillus acidophilus (2 strains) ....... 6 billion CFU
Bifidobacterium bifidum ......................... 1 billion CFU
Bifidobacterium lactis ............................. 1 billion CFU
Fructo-oligosaccharides ................................ 800 mg
May contain up to ................................. 12 billion CFU
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Intensive Phase
Take ½ teaspoon twice daily after
meals for one month. Please note, for
more severe intestinal upsets you may
safely take 1 Tablespoon twice daily.
Clinical Considerations
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During and post-antibiotic use
Acute intestinal upset (food poisoning,
stomach ache)
Digestive disturbances (bloating, gas)
Candidiasis (yeast infections)
Bacterial Vaginosis
Parasitic infections
Chronic Fatigue Syndrome
Bowel problems (constipation,
diarrhea, IBS)
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Intermediate Phase
Take ¼ teaspoon one or twice daily
for one month.
Clinical Considerations
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General illness (cold, flu, mild infection)
Stressful life style
Parasitic infections
Digestive problems (bloating, gas)
Constipation
Excessive alcohol consumption
Bowel problems (constipation,
diarrhea, IBS)
Chronic Fatigue Syndrome
Candidiasis
Genestra Brands
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Each vegetable capsule
contains:
Lactobacillus acidophilus (two
human derived strains)....... 6
billion CFU
Bifidobacterium bifidum.......1
billion CFU
Bifidobacterium lactis.......1 billion
CFU
Fructo-oligo-saccharides
(FOS)....... 200 mg
May contain up to.......12 billion
CFU
*All HMF probiotics are gluten
and casein free.
Genestra Brands ~ Forte
Tx recommendations
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Intermediate Phase
Take 4 capsules daily (2 caps twice
daily after meals)
Clinical Considerations
 General illness
 Stressful life style
 Parasitic infections
 Digestive problems (bloating, gas)
 Constipation
 Excessive alcohol consumption
 Bowel problems (diarrhea, IBS)
 Chronic Fatigue Syndrome
 Candidiasis
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Maintenance Phase
1 or more capsules daily after meals
Clinical Considerations
 Maintain Health of the digestive
system
 Prevention of colds and flu
 Stressful life style
 Digestive problems (bloating, gas)
 Occasional Constipation
 Prevention of Candidiasis & yeast
infections
Genestra Brands
HMF Natogen (previously Neogen)
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Ingredients and Suggested Use
Each Scoop (100 mg) Contains
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Lactobacillus acidophilus, guaranteed
1 billion CFU
Lactobacillus casei
1 billion CFU
Bifidobacterium infantis
May contain up to 4.5 billion CFU
Lactose base (an important energy source for breast
and bottle fed babies derived from milk but free of
casein)
Recommended Dosage
Infants: Add one level scoop daily into the feeding,
or dip your baby finger into scoop and give to infant
to suckle on throughout the day.
*All HMF probiotics are gluten and casein free.
Genestra price list
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Probiotics & Prebiotics
HMF______________________ 60 caps _ 10.50
HMF Forte _________________ 60 caps _ 15.00
HMF Forte ________________120 caps _ 27.50
HMF Neogen _________________ 6 g __ 10.50
HMF Powder_________________ 60 g __ 13.25
HMF Replete _______________ 7 sachets 17.25
HMF Super Powder ___________120 g __ 26.00
FOS + L-Glutamine___________ 60 caps _ 8.25
Genestra Brands
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Seroyal, a Natural pharmaceutical company founded in 1984, manufactures
and distributes the extensive line of Genestra Brands nutritional and
botanical products and is the North American distributor for the renowned
Unda Homeopathic line. Ask your registered practitioner for more
information.
Genestra Product Groups
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Amino Acids & Proteins
Antioxidants & Oral Chelations
Botanical Combinations & Single Tinctures
Calcium-Magnesium Complexes
Digestives & Probiotics
Essential Fatty Acids & Phospholipids
Female & Prenatal Formulas
Homeopathic, Endocrine & Glandular Extracts
Minerals & Glucosamines
Standardized & Phytonutrients
Topical Care, Creams & Clinical Aids
Vitamin-Mineral Complexes
Vitamins A, C, E & B Complex<>
Genestra philosophy
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Our products are based on scientific rationale using only the purest, highest quality, natural, raw ingredients
available. We work closely with you and your peers to incorporate the latest research and clinical findings into all
our products.
Seroyal’s products are made with care and attention to every detail. To ensure product uniformity, each ingredient
is accurately weighed, tested and precisely mixed. To retain the full healing properties of each component, all
tablets are cold-pressed and a low pressure compressing process is used. This unique method does not involve
the use of heat as is the standard practice in the industry. No lubricants or fillers are used during our
encapsulation process whenever possible. We use the purest source of lubricant available, such as biodegradable
vegetable cellulose, to maintain consistent capsule weight and content conformity.
Genestra’s vegetable capsules are free of pesticides, preservatives and additives, tested by government-approved
independent laboratories to ensure quick dissolution and disintegration. We guarantee that the disintegration time
does not exceed 20 minutes from the time of ingestion for capsules, and 30 minutes for all our tablets. We
regularly test our capsules and tablets to confirm weight variation and ingredient potency.
When manufacturing the Genestra products, we follow the procedures outlined in the Good Manufacturing
Practices. We ensure precision and objectivity during testing by contracting government-approved independent
laboratories to assay and verify each ingredient for every product in each lot. We reconfirm each ingredient’s
potency, weight variation, disintegration time and the absence of heavy metals, bacteria, E. coli, salmonella,
yeasts, mold and other contaminants.
About Genestra Brands
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Are HMF products shipped with an ice pack?
No. But, after extensive product testing and new freeze drying technology performed
by Genestra, it was concluded that the ice pack did not make a difference during
shipping since the product potency was still well over 100% label claims when
shipped with ice or no ice. The manufacturer states that it is no longer necessary to
ship the HMF products with an ice pack for these reasons:
Genestra has added in 50% more probiotic than what the label guarantees per bottle.
For example, HMF Forte is guaranteed to have 6 billion L. acidophilus per serving, but
there are 12 billion present at time of manufacturing and it is kept frozen until
shipping.
October 2004: The manufacturer has increased product stability again, allowing the
probiotics to last up to 6 months at room temperature holding their GUARANTEED
minimum potency on label!
You will receive your HMF probiotic directly from the manufacturer in about 3-5 days.
This product is very fresh and has not been sitting around on our shelves. And, you
are guaranteed it will contain 50% more than what the label states.
How do I travel with my HMF probiotics?
We highly recommend you take your probiotics with you on all trips and vacations
since their potency will last for up to 6 months at room temperature un-refrigerated.
But, when possible and if convenient, we recommend you store your probiotics in the
freezer or refrigerator, especially if you plan to preserve freshness of your product for
months or years.
What is Clostridium Difficile
(C.difficile)?
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Clostridium difficile, or C. difficile (a gram-positive anaerobic, SPORE forming bacterium)
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Is now recognized as the major causative agent of colitis (inflammation of the colon) and diarrhea that may occur
following antibiotic intake. C. difficile infection represents one of the most common hospital (nosocomial) infections
around the world. Laboratory studies show that when C. difficile colonize the gut, they release two potent
toxins, toxin A and toxin B, which bind to certain receptors in the lining of the colon and ultimately
cause diarrhea and inflammation of the large intestine, or colon (colitis). This bacterium is primarily
acquired in hospitals and chronic care facilities following antibiotic therapy (symptoms may be delayed until 6-8
weeks after antibiotic use). In addition to antibiotic use, chemotherapy and hospitalization, another risk factor for
developing C.difficile diarrhea is simply advancing age. One study conducted in Sweden found that individuals
older than 60 years of age are 20 to 100 times more likely to have C.difficile in their stools compared to 10-20 year
olds (Barlett, 2002).
Symptoms of C.difficile?
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Symptoms of C.difficile diarrhea vary widely in severity. Some individuals experience recurrent mild-to-moderate
diarrhea, wither others suffer from recurrent bouts of severe abdominal and back cramping, frequent loose and
watery, greenish, foul-smelling stools, flatulence, fever, as well as variable amounts of mucus and blood in the
stool. C.difficile diarrhea with accompanying inflammation of the colon can lead to toxic dilation of the colon,
perforation of the colon, dehydration, loss of water volume, shock, and death. The toxins produced by
C.difficile can also trigger a whole host of extra-intestinal complications, including joint pain and
sleep disorders.
C.Difficile Tx
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C.difficile be treated effectively?
Although C. difficile infection usually responds to antibiotic
treatment with metronidazole or vancomycin, approximately 20 to
25% of patients will experience re-appearance of diarrhea and other
symptoms weeks or even months after initial therapy has been
discontinued. When antibiotics are used to eradicate C.difficile, the
antibiotics kill many of the “good” gastrointestinal flora species, but
only kill non-spore forms of C.difficile. The C.difficile spores are still
present. In order to eliminate C.difficile spores you need to have
some “good” normal flora present. How can I re-establish my
gastrointestinal flora to eliminate C.difficile?
Numerous of studies have proven certain probiotics to be a
successful solution for recurrent C.difficile diarrhea.
Saccharomyces boulardii
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Saccharomyces boulardii
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A non-disease causing yeast that survives
passage through the intestinal tract, unaffected
by antibiotics (although it will be killed by
antifungal drugs).
Based on preliminary data indicating that this
yeast could prevent antibiotic-associated
diarrhea.
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Numerous studies, have gone on to prove
Saccharomyces boulardii, as an effective treatment
for active C.difficile diarrhea.
Saccharomyces boulardii disrupts toxins that would
normally irritate the intestines,
In addition, Saccharomyces boulardii stimulates
the intestinal immune system to secrete C.difficile
toxin A-specific antibodies (IgA) in the gut (Qamar
et al., 2001).
* It is then eliminated after supplementation is
stopped.
Allergy Research Group
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http://www.allergyresearchgroup.com/pro
ddesc/category/microbal.htm
Thorne
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Lactobacillus sporogenes
Lactobacillus sporogenes represents a
breakthrough in Lactobacillus
supplementation
a safe, stable, effective, L(+)-lactic-acidproducing organism.
Lactobacillus sporogenes binds cholesterol
in the gut, and may inhibit the cholesterolproducing enzyme HMG CoA Reductase.
It requires no refrigeration or special
handling.
Resources
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http://www.rockwellnutrition.net/home.asp
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http://www.gla.ac.uk/departments/humannutrition/students/resources/meden/Infection.pdf
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Manufacture sites
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http://www.seroyal.com/seroyal/Navigation/ProductLinePublic/Genestra_Line.htm
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http://www.allergyresearchgroup.com/proddesc/category/microbal.htm
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http://www.thorne.com/altmedrev/fulltext/micro.html
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Microbial Ecology and Dysbiosis in Human Medicine ~ Excellent Article
jefechi.com/probiotics