Transcript Genetics in the genomics age

Microarray analysis
each spot represents
one gene
Yellow: no change in
gene expression
Green: the gene is
Red: the gene is
turned off in the tumor
turned on in the tumor
Analyzing
Human Breast
Cancer Types
By Microarray
Analysis
Identifying genes
whose expression
changes at specific
stages of the cell cycle
day night day night day night
Circadian Rhythms
and Sleep
Genes whose
expression changes
during the day
in fruit flies
(and people)
Implications for
sleep disorders
Arp3
Arp3
Arp2
Arc40
Arc35
18
19
15
35
Arp2
Arc19
Arc18
Arc15
40
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Fig. 1. Representation of chromosome V incorporating genetic footprinting data. Each box is colored to summarize the
results obtained to date from genetic footprinting. Mutant phenotypes: Q1, all selections, <75% population growth rate;
Q2, all selections, 75 to 85% population growth rate; Q3, all selections, 85 to <100% population growth rate. Genes in
which mutations gave distinctive phenotypes under specific selections are colored according to the selection(s) affected,
as follows: M: (dark green),: minimal medium;. L (teal),: lactate medium;. H (orange),: high temperature;. C (brown),:
caffeine;. S (yellow),: high salt;. X (light green),: mating;. WT (dark blue),: wild-type for all selections;. NR (grey)
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bim1 x rad54