Transcript cardiovascular disease, genetic alterations, and gene therapy

CARDIOVASCULAR
DISEASE, GENETIC
ALTERATIONS, AND GENE
THERAPY
BY:
Mary Harrell, Farah Fevrier, Kareen Carty,
Daniel Omotola, and Trey Palmer
PROBLEM
 With
human gene mapping complete,
does prevention of cardiovascular
disease (CVD), the nation’s leading
killer, lie within human genes?
PROBLEM

Risk Factors For CVD
– Tobacco Use
– Hypertension
– High Levels of
Cholesterol
– Physical inactivity
– Diabetes
– High Triglyceride
Levels
– Obesity
– Psychological & Social
Factors
– Heredity
– Aging
– Male
– Ethnicity
– Syndrome X
PROBLEM

Risk Factors For CVD
– Tobacco Use
– Heredity
– High Levels of
Cholesterol
– Physical Inactivity
– Diabetes
– High Triglyceride
Levels
– Obesity
– Psychological & Social
Factors
– Hypertension
– Aging
– Male
– Ethnicity
– Syndrome X
BACKGROUND INFORMATION

Facts about Cardiovascular Disease
–
–
–
–
Mortality of CVD is 1½ times that of cancer
Quality of life diminished for 25% of population
Strokes account for 1/6 of all CVD hospitalizations
Congestive heart failure is most frequent cause of
hospital visits by people over 65
– Impact is far reaching
POSSIBLE SOLUTIONS
Gene Transfer
 Modification

–
–
–
–

Genetically defective contractile proteins
Myocardial cells
Cardiac protein profile to rebuild muscle
Enhance contractility
Replacement
– Artherosclerosis prevention

Regrowth
– Alternatives to invasive surgery
– Repair damaged tissue and improve heart function after
infarction
BEST SOLUTION

Regrowth with the use of Stem Cells
– Proven successful on mice
– Testing on non-human primates to begin
– Angiogenesis “opens up” blocked vessels
– Effectiveness on cardiac muscle
CONCLUSION

With human gene mapping complete,
does prevention of cardiovascular disease
(CVD), the nation’s leading killer, lie within
human genes?

Push for gene therapy with stem cells on
humans
REFERENCES
1.
2.
Core Concepts In Health, by Insel & Roth pgs. 10, 428436, 446, 454, 483
Primary site – CVD/gene therapy paper
http://oak.cats.ohiou.edu/~ed170793/paper.htm
3.
Common viriants of most human genes
www.ornl.gov/hgmis/publicat/hgn/v10n1/13lander.html
4.
Understanding DNA variations
www.ornl.gov/hgmis/publicat/hgn/v10n1/06snps.html
5.
Explaining the human genome project
www.nhgri.nih.gov/Policy_and_public_affairs/Communications/Pu
blications/Maps_to_medicine/about/html
REFERENCES
6.
Angiogenesis
7.
Stem cells
8.
Gene clues and CVD
9.
Use of stem cellls on mice
www.bioportfolio.com/news/leaddiscovery_10.htm
www.genome.gov/page.cfm?pageID=10000345
www.the-aps.org/press_room?release2-19-02.htm
www.seniors.gov/articles/0401/heartattack