Transcript Differential Gene Expression

Differential Gene Expression
Differential Gene Transcription
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What are the major differences between
prokaryotic and eukaryotic genes?
Differential Gene Transcription
Differential Gene Transcription
Differential Gene Transcription
Differential Gene Transcription
Promoters
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How do promoters
work?
Enhancer
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How is an enhancer different from a
promoter?
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Activates use of promoter
Activates promoters on same strand
Doesn’t need to be adjacent to gene
Doesn’t need to be upstream
Enhancer
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How can one identify
presence of an
enhancer?
Why are they so
important?
Transcription Factors
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What are the major structural domains of
these molecules?
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DNA-binding domain
Trans-activating domain
Protein-protein interaction domain
Transcription Factors
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What is MITF?
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Trans-activating domain
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Protein-protein interaction
domain
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DNA-binding domain
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DNA
Transcription Factors
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Why is PAX6 such an important molecule?
Silencers
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What are silencers?
Transcriptional Control
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Of what value is DNA
methylation?
How has this been
demonstrated
experimentally?
How does methylation
work?
Transcriptional Control
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What are insulators?
Transcriptional Control
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How does dosage
compensation
influence
transcription?
What are Barr bodies?
How does this relate
to calico cats?
RNA Processing
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What is the difference between nRNA and
mRNA?
RNA Processing
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How is differential
splicing of nRNA
accomplished?
What is the difference
between genome and
proteome?
Translational Control

What are some of the factors that influence
gene expression at the level of translation?
Translational Control
Posttranslational Regulation

What is meant by this level of regulation?
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How can it occur?
Controlling Gene Expression
Controlling Gene Expression
Controlling Gene Expression