Transcript Decapeptyl®

GnRH and Triptorelin


Isolation, identification and synthesis of GnRH
originally carried out by Schally & Guillemin
Natural GnRH =
peptide chain of
10 amino acids
GnRH and Triptorelin

Replacement of the
amino acid in
position 6 (glycine)
by-tryptophan
Main differences between
naturally occurring GnRH and GnRH agonists


Higher affinity
for the GnRH
receptors in the
pituitary
Longer plasma
half-life
(more resistant
to enzymatic
breakdown in
the blood)
Action of
Decapeptyl
®
The ‘flare-up’
Downregulation
Pituitary downregulation
The competitors