Transcript Powerpoint

Deadline = line + dead
think about it
deadline |ˈdedˌlīn|
noun
1 this definition not relevant
2 historical a line drawn around a prison beyond which prisoners were
liable to be shot.
Does it really make sense to designate that period at the end
as the target as opposed to that at the beginning?
Is it really the case that your schedule is such that all
available times just happen to fall at the last minute?
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Beating Tamiflu
Themes:
Evolution: then and now
amino acids, mutations, folding: they matter
How evolution
happens
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Good ideas are rewarded not sought/planned
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There’s no mechanism for foresight, so it cannot be that way
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Just passin’ through
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http://www.ch.ic.ac.uk/local/projects/sanderson/images/lifecyc.gif
Tamiflu: you shall not pass!
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a.k.a. oseltamivir
http://en.wikipedia.org/wiki/File:Oseltamivir-3D-balls.png
And it goes like
this...
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Note: this is modeled, not a crystal structure
http://www.ks.uiuc.edu/Research/influenza/
Cell sorting
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Laser is like a black light-molecules GLOW a different
color than they are being hit
with
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In our case, GFP (green) and
cherry (you guess it)
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Phylogenetic trees
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Participants: to your spot on the tape!
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Observers: watch & predict outcome and what it’s good for
Each round:
Copy any changes your parent already has
Determine position of your new change by adding #s (0 = none)
Randomly change to new base & mark (A, G, C, U)
Turn to your kids & repeat
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Supplemental note
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What we did was just the tip of the iceberg
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among other things, the same basic thinking can be done to
reconstruct a tree even if we only have the current [last] generation
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try putting your thumb over any individual and seeing if you can
guess their sequence by looking at their children
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Supplemental
Stuff you might find useful
Supplemental
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Cartoon of infections & tamiflu action (contr. Katie F12)
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http://www.youtube.com/watch?v=0qCTyKrhVWc
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Unused
This was a graphical presentation of what we
ended up doing ‘live’ in class. It tries to make
the same points: the ‘correct’ reconstruction
has fewer total changes (parent-child
sequence alterations) than a random one
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Now what???
What information allows you to make good inferences
about who is most related?
Who gave rise to whom?
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Which makes sense?
Or this?
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How about this?
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