Transcript Document

Lecture 16
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Energy generation overview
Cellular compartments
Where does Glycolysis occur?
Where does TCA occur?
Cytosol
Mitochondria
Cellular compartments
http://www.sabiosciences.com/pathwaymagazine/minireview/mitchondrial_energy_metabolism.php
Pyruvate  Acetyl CoA
What’s CoA?
Pyruvate  Acetyl CoA
Pyruvate  Acetyl CoA
Pyruvate  Acetyl CoA
Regulation layer one: Within cell
Regulation layer two: Signaling
Sound familiar?
Nicotinic acid  NAD
Riboflavin  FAD
Pantothenic acid  CoA
Biotin
VITAMINS!
Vitamins are metabolic cofactors
Give rise to different “carriers”
Need small amounts – cyclic!
Energy generation overview
The TCA
TCA Regulation
TCA Regulation
TCA Regulation
TCA Regulation
TCA energy production
TCA energy production
TCA energy production
Glucose energy production