Transcript PPT - Blood Journal

Immune reconstitution to cytomegalovirus after allogeneic
hematopoietic stem cell transplantation: impact of host
factors, drug therapy, and subclinical reactivation
by Morgan Hakki, Stanley R. Riddell, Jan Storek, Rachel A. Carter, Terry StevensAyers, Patrick Sudour, Kristen White, Lawrence Corey, and Michael Boeckh
Blood
Volume 102(8):3060-3067
October 15, 2003
©2003 by American Society of Hematology
Impact of subclinical pp65 antigenemia (≥ 1cell/slide) during the first 80 days on recovery of
CMV-specific CD4+ Th responses and CD8+ CTL responses at 3 months among patients
receiving prophylactic ganciclovir at engraftment.
Morgan Hakki et al. Blood 2003;102:3060-3067
©2003 by American Society of Hematology
Proportion of patients who reconstituted CMV-specific CD4+ Th and CD8+ CTL function at 3
months when receiving 0, less than or equal to 1 mg/kg/d steroids, or greater than or equal to 2
mg/kg/d in the 2 weeks preceding sample collection.
Morgan Hakki et al. Blood 2003;102:3060-3067
©2003 by American Society of Hematology
Effect of absolute CD4+ counts on CD4+ Th function (CMV and PHA) and CD8 counts on CMVspecific CD8+ CTL response.
Morgan Hakki et al. Blood 2003;102:3060-3067
©2003 by American Society of Hematology