Transcript Pulmonary Embolism Extraction Catheter Development

Pulmonary Embolism Extraction
Catheter Development
Trip Cothren
Lauren Nichols
Dustin Temple
Advised by: Dr. Michael Barnett, VUMC
Cardiology
Problem
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There are over 600,000 cases of
pulmonary embolisms annually in the
United States, which result in nearly
60,000 fatalities.
Blood thinning, thrombolytics are
dangerous
Need a catheter that can quickly and
effectively remove pulmonary embolisms
Goals
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The goal of this project is to design a catheter that
can efficiently remove an embolism from the
pulmonary artery. The main goals of the project are:
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To research and evaluate current technology in pulmonary
embolism extraction
To design a catheter that can successfully remove
embolisms percutaneously and completely without damage
to the patient
To produce a feasible prototype of our design
Existing Work
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Much catheter work
done to remove
embolisms in the brain
Cardiac catheters
typically focus on
placing stents in
coronary arteries
Few existing PE
extraction catheters
AngioJet Example
Trellis Device
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A peripheral infusion system that
disperses a clot-lysing drug at 500-3000
rpm’s.
Demonstration Video
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Device Website
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Potential Problems
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Hemolysis causes release of adenosine
when cells lyse
Bradycardia or heart failure
Renal failure
Unpredictable thrombolytic tolerance
Mechanical damage to vessel wall
Design Parameters
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Approximately 2 m in length
Device approximately 12 mm in diameter
Agitation and extraction mechanism
Does not harm vessel walls
Does not impede blood flow
Easily maneuverable
Function Parameters
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Time frame of < 1 hr
Embolus located via x-ray angiography
Typically done by interventional
radiology or cardiothoracic
Clot age affects composition
Downstream protection not as important
Do not want systemic thrombolytics
Current Work
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Decide local
thrombolytic elution
Obtain catheter from
VUMC to examine
Schedule a surgery
observation
Research best
modeling mechanism
for demo and CAD
model
Future Work
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Meet with Dr. Barnett and Dr. Bream to
discuss feasibility of ideas
Contact Dr. Byrne in VUMC
Cardiothoracic Surgery
Create CAD model
Assemble team of contacts in VUMC
and BME department
References
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http://www.medgadget.com/archives/img
/sidcath.jpg
http://www.socalcardiology.com/media/a
ngiojet.jpg
http://www.lexmed.com/images/cathphot
o2.jpg