Cat # PKI-AG1478 Tyrphostin AG 1478 15875 Gaither Drive Gaithersburg, MD 20877 FAX. 301-560-4919 Small 25 mg Large 100 mg TEL. 301-330-5966 Email: [email protected] Web: www.signagenlabs.com This product is for laboratory research ONLY and not for diagnostic use Description: References: Highly potent and selective inhibitor of epidermal growth factor receptor kinase (IC 50 = 3 nM and > 100 µM for Her2-neu and PDGFR). Physical and Chemical Properties: Molecular Formula: C 16 H 14 ClN 3 O 2 .HCl Molecular Weight: 352.22 CAS Number: [153436-53-4] Physical Appearance: Cream solid Structure: 1. Levitzki and Gazit (1995) Tyrosine kinase inhibition: an approach to drug development. Science 267 1783. 2. Han et al (1996) Tyrphostin AG 1478 preferentially inhibits human glioma cells expressing truncated rather than wild-type epidermal growth factor receptors. Cancer Res. 56 3859. 3. Eguchi et al (1998) Calcium-dependent epidermal growth factor receptor transactivation mediates the angiotensin IIinduced mitogen-activated protein kinase activation in vascular smooth muscle cells. J.Biol.Chem. 273 8890. Solubility: DMSO to 5 mM Stability and Solubility Advice: Some solutions can be difficult to obtain and can be encouraged by rapid stirring, sonication or gentle warming (in a 45-60°C water bath). Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide. 2006 SignaGen Laboratories Our standard recommendations are: SOLIDS: Provided storage is as stated on the product label and the vial is kept tightly sealed, the product can be stored for up to 6 months from date of receipt. SOLUTIONS: We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials at 20°C or below and used within 1 month. Wherever possible solutions should be made up and stored on the same day. Storage: Stable for 12 months at -20 0C from the date of shipment. Product shipped at ambient temperature.