Transcript The Use of Bioinformatics and Functional Genomics in the Analysis

Clinical Bioinformatics: the
need for CBAS and SCBC in
Applied Sciences?
Dr James Mah
MBBS(Lon), BSc(Hons,Lon).
Chair, CBAS 2009 Singapore
Email: [email protected]
Clinical Bioinformatics
• The use of informatics tools and techniques to
study and analyse biomedical and genetic data
• Involves the development of new tools and
algorithms to solve biomedical issues
• Involves new discovery of biomedical knowledge
and know how
• Covers and overlaps with many disciplines and
fields in applied sciences
Clinical/biomedical example……..
CLINICAL BIOINFORMATICS
• New methods to rapidly and conveniently screen any
genetic variant
-probability of association with disease risk
-probability of treatment outcome
The Clinical Bioinformatics Cycle
Egs
Clinical
Bioinformatics
(NEW!)
Results?
DISEASE
Cure
HEALTH
Prevention
CANCER RISK PREDICTION
Personalised Medicine
TREATMENT OUTCOMES eg TOXICITY
DRUG
(outcome)
DEATH
(Survival outcome)
CASE STUDY 1 –DRUG TREATMENT OUTCOME MODEL
Gene VKORC1(Vitamin K epoxide reductase complex 1) story
a)Study in European-American population (Rieder et al 2005)
b)Study in Asian population (Lee SC et al 2006)
CASE STUDY 2 –SURVIVAL OUTCOME MODEL
THE GEMCITABINE NON-SMALL CELL LUNG CANCER STORY
POTENTIAL USES OF NEW
BIOMEDICAL IMAGING TOOLS
• Screening
For suspicious lesions
-population screening
Eg for breast cancer detection
-epidemiological studies
-risk stratification
– cancer prevention, treatment
programmes
1st Clinical Bioinformatics Symposium on
Applied Sciences (CBAS) 2009
• Promote awareness of Clinical Bioinformatics and its
applications in biomedical sciences and healthcare
• Sharing of views by renowned speakers invited to tackle
complex and diverse topics in Clinical Bioinformatics
• Networking session and SCBC to allow participants to
showcase their work to foster inter-disciplinary
collaborations
• Help foster the Clinical Bioinformatics Cycle
TIME
CBAS PROGRAMME SCHEDULE
8:30 AM
Registration
9:00 AM
CBAS Opening by Chair, JAMES MAH
TITLE:Clinical Bioinformatics: the need for CBAS and SCBS in Applied Sciences?
9:20 AM
Keynote Plenary: WONG TIEN YIN
TITLE: Translational research and Bioinformatics in Singapore: advances, breakthroughs
and initiatives- a clinical prospective”
10:15 AM
Special Q&A
10:30 AM
Morning Tea Break
11:00 AM
Plenary 2: SU YI
TITLE: Biomedical modelling with clinical applications
11:30 AM
First Singapore Clinical Bioinformatics Consortium Meeting
12:30 PM
Lunch Break
1:20 PM
1:30 PM
Introduction to Afternoon session by Chair, JAMES MAH
Plenary 3:WAYNE MITCHELL
TITLE: Translational research and drug discovery:can bioinformatics help?
2:00 PM
Plenary 4: LEE HWEE KUAN
TITLE: Computer vision and pattern discovery for bioimages: An emerging field in
bioinformatics
2:30 PM
Plenary 5: CAROLINE LEE
TITLE: Pharmacogenomics and personalized medicine- advances and possible roles of
bioinformatics
3:00 PM
Sponsor Talk: Chris Molloy, VP Corporate Development, ID Business Solutions
TITLE: Translational Medicine and Biomarker discovery: an informatics issue
3:30 PM
Afternoon Tea Break
4:00 PM
Plenary 6: LUN KWOK CHAN
TITLE: Medical Informatics: past, present and future
4:30 PM
Q&A/Networking/Collaboration presentations II
5:20 PM
Plenary panel discussion: Clinical Bioinformatics:Present and Future
The Singapore Clinical
Bioinformatics Consortium (SCBC)
• Part of CBAS to continue inertia and initiative
• Seek representatives from each institution to
strengthen ties and build up strong links for
collaboration in the field of Clinical
Bioinformatics
• Potential aims would be to initiate key or core
project areas with potential for development both
locally as well as regionally
The Singapore Clinical
Bioinformatics Consortium (SCBC)
• Tie-ups with industry and pharmaceutical
companies are also encouraged
• Invitation to be part of this exciting
Consortium as committee members to
spearhead and drive new clinical
bioinformatics projects both regionally and
internationally
The Singapore Clinical
Bioinformatics Consortium (SCBC)
• Invitation for contribution in but not limited to:
-Biomedical Imaging
-Translational Research
Eg Bench-to-bedside or personalized medicine
-Genomics
Eg functional annotation of genetic variants with respect to complex/clinical
diseases
-Drug discovery
Eg novel drug target identification and discovery
Acknowledgements
•
•
•
•
•
Dr Victor Tong and InCoB 2009 committee
A*STAR
All our sponsors and dedicated supporters
Distinguished speakers
Dedicated CBAS 2009 organising committee:
Tze Hau, Meng Ling, Luke, Winnie, all volunteers
• Delegates and attendees
• All those indirectly or directly made this event
possible