Transcript Presentation #4

Automated Metered Dose Inhaler
Presentation #4 (03/22/04)
Presented By Group 11:
The “MDI Auto-Maniacs”
Maria del Carmen Carrillo
Jennifer B. Struble
Loyrirk Temiyakarn
Problem Definition

Automatic Metered Dose Inhalant (MDI)
delivery device:
 Electromechanical,
in-hospital inhalant drug
delivery system
 Patients are mechanically ventilated and
sedated
 Medication delivered automatically as
prescribed electronically
 Medication must be well shaken
(homogenized with propellant)
Background

What is a Metered
Dose Inhaler?



Who Uses Them?


pocket-sized handheld inhaler
delivers standardized dose of
medication for bronchodilation
Patients with asthma or
chronic obstructive pulmonary
disease (COPD)
Setting?


Critical patients in hospitals
Prescriptions for outpatient or
in-home use
Existing Methods

Methods in-use


Manual administration
Patent Search

QuickTime™ and a
TIFF (LZW) decompressor
are needed to see this picture.
Automatic
methods are
NOT for
mechanically
ventilated
patients
Design Factors






Integration with existing
endotracheal tubing
Homogenization with
propellant
Delivery of medication
into ventilation system
Tubing length
Synchronization of
delivery with breathing
Software/Automation


User interface
Prescription error
checking
Project Status

Preliminary Research
Complete


Completed Research





Standard MDI
Endotracheal Tubing
Connectors
Ventilators (Siemens
Servo I)
Types of Medication
Continuing Research

Homogenizer
Working Design:
Using Prefabricated Canisters

Integrated with existing
tubing


Homogenize


In-line using
AeroChamber
Pneumatic Actuator
Laptop-based
prescription entry

Similar to error reduction
system, Guardrails®
Safety Software, in Alaris
“Smart” IV Pump
Shaking = Homogenization

Key obstacle homogenization
 Actuator homogenize and
administer Albuterol

Pneumatic



Simple singular
directional motion
Control stroke length
Detect position
Experiment on Homogenization

1.
2.
3.
4.
Overall - Difficult to quantify
and so based on subjective
analysis
Soft vs. Vigorous Shakes Soft more effective
Various Vigorous Shakes One worked better than two
Various Soft Shakes - Five
better than three or ten
With the Spacer - ineffective,
has to be inhaled to leave the
spacer
Timeline

Completed Work

Preliminary research
 Clearly defined design
factors



Through Innovation
Workbench
Testing with Albuterol
Current Work

Discuss with Festo rep.
 Order more components
to start building prototype


Actuator (pneumatic)
Building Model A

Timeline




Order parts ~ immediate
Model A ~ End of March
Testing ~ End of March
Final prototype ~ April

Software included
References
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http://familydoctor.org/040.xml
http://www.medlineplus.com/
http://www.alarismed.com/na/press/presskit_b
kgd.shtml
http://www.drgreene.com/21_1377.html
http://www.med.umich.edu/anes/tcpub/glossa
ry/anesthesia_glossary-05.htm
http://www.rattus.com/catalogpagesearch5ak
ent.asp?page=5
Hudson RCI. AnaConDa™ Principles of
Operation. 2003