Professor, Leslie Dan Faculty of Pharmacy
Room 1003, Pharmacy Building
Post-Doc PK & Mol. Pharm.
U of A
U of A
Current Professional involvement:
Associate Editor: Clinical Pharmacology &
President: Canadian Society of Clinical
• Understanding Individual Variability in Drug
Disposition and Response
– Drug-disease Interactions
– Contribution of ABC Drug Efflux Transporters
• Improving Tumor responsiveness to
– Drug Resistance
– Dosing and Drug Delivery Strategies
Mr. Sarabjit Gahir,
BSc. Pharm (2004)
Room 1040 LDFB
Email: [email protected]
Introduction to 2nd term of PHM 324
Assignments & Exam
– Marks & Format
• How you can do well in the course
• In this term we will build upon the
fundamental PK concepts taught in the 1st
term in order to understand, describe and
predict the pharmacokinetics of drugs in
clinical settings comprised of different
patient population groups.
“If it were not for the great variability among individuals,
medicine might as well be a science and not an art.”
Sir William Osler, 1892
Goal of 2nd Term: PERSONALIZED MEDICINE:
Delivery of the right drug to the right patient at the right dose
1) To develop competence in adjusting drug and dosage
regimens for patients based on individual patient factors
and what is known about the pharmacokinetics of that drug.
2) To develop strategies to enable incorporation of “drug &
dosage individualization” in a busy clinical setting.
Mondays 9-10 am PB B250
Thursdays 2-3 pm PB B150
2-3 tutorials will be organized based on your
Jan 17, 21
Clearance Concepts Revisited
Environmental Factors in Variable Drug Response
Pharmacogenetic Factors in Variable Drug Response
Hepatic CL & Dose adjustment based on Hepatic
Feb 4, 7 :
Renal CL & Dose adjustment based on Renal Function
Feb 11, 14: Dosage Adjustment in Special Populations
Feb 18, 21: Reading Week Assignment # 1 handed out by Feb 15
Feb 25, 28: Protein Binding Concepts
Mar 3, 6:
Dr. Shirley Teng
Mar 10-20: Therapeutic Drug Monitoring & Clinical PK
Pain Week (No class). Assign. # 2: Case Study Pain Management
Mar 31- Apr 7: Nonlinear PK & Therapeutic Monitoring
An additional tutorial can be scheduled in April
(coordinated with class schedule) to assist in
preparation for final exam.
Class requests for tutorials on specific subjects
can be arranged.
• Several changes in lecture material since
• Exams and assignments will reflect what is
covered in lectures and assigned readings
for this year.
• Hardcopy of each lecture will be provided
to students in advance of class. Space
provided next to each slide for notes.
• Lecture notes will also be provided on
website prior to final exam.
Applied Biopharmaceuticals &
Pharmacokinetics 5th Edition
L. Shargel S. Wu-Pong & A. Yu
-Highly recommend reading relevant sections.
Will post several review articles on website.
Student comment (06):
“the textbook readings should really be required”
• There will be 2 assignments, each worth 7.5%
of the final mark.
• Each assignment should take 4-6 hrs to
complete. Students will have at least 2 weeks
to complete assignments.
• Worth 35% of final mark
• Exam format will be mix of calculations
(show your work), short answer and multiple
• While exam will be based on material from
this term, students must know essential PK
calculations/ concepts from last term.
– I will discuss what I consider essential concepts
in my lectures.
How to do well in the course
1. Attend class
2. Do practice problems (from class, old exams,
textbooks) and assignments to ensure you
understand how to do the calculations.
3. Review relevant sections in textbook.
4. Do your own assignments.
Mondays 3-4 pm
Will be out of country: March 3rd- 10th
• Emails must have subject line and should be from
a U of T address.
• If the question can not be adequately answered
with a brief response, I will request that the
student arrange for a meeting with me or the TA in
• In order to ensure fairness among students, Email
questions and answers may be posted on website
or distributed to class via email.
• Will respond to emails during regular working
hours (not on weekends or evenings) and response
times may vary.
Helpful Websites for overview of
concepts and practice problems
• Volunteers to assist in developing new
outline for the Pharmacokinetics/
Personalized Medicine Course?