Center for Translational Neuroscience Distinguished Speaker Series Rayford Auditorium, Biomed II Bldg., 12 noon Tuesday, February 2, 2010 Sleep, Anesthesia, & Mental Health: Mechanistic Insights from Neuropharmacological and Neurochemical Studies Helen A. Baghdoyan, Ph.D. Professor of Anesthesiology and Pharmacology University of Michigan School of Medicine Ann Arbor, MI The same neural systems that evolved to generate states of sleep and wakefulness are preferentially involved in generating anesthetic states. Similarly, sleep/wake states and mental states are generated by overlapping brain regions and neurotransmitters. All psychiatric disorders are characterized by disrupted sleep, and sleep loss exacerbates psychiatric symptoms. Use of in vivo microdialysis for drug delivery to specific brain regions of behaving animals while collecting endogenous neurotransmitters is providing unique insights into the mechanisms by which states of arousal are generated. This lecture will present an overview of recent advances in understanding neurotransmitter interactions in brain regions that regulate arousal states. Studies of GABA, hypocretin/orexin, acetylcholine, and adenosine in the pontine reticular formation and prefrontal cortex will be highlighted. Identifying neurotransmitter interactions that regulate behavioral states is essential for understanding the neurochemical substrates of mental health.