Transcript Document

Image-Guided Interventions; Ultrasound
• Group Members
– Mehrdad Negahban (Eng. Mechs., UNL)
– Jiashi Yang (Eng. Mechs., UNL)
– Jason MacTaggart (Surgery, UNMC)
– George Gogos (Mech. Eng., UNL)
– Mehmet Can Vuran (Comp. Sci. Eng., UNL)
– Feng Xie (Internal Med., UNMC)
– Dong Wang (Pharm. Sci., UNMC)
– Greg Bashford (Bio. Syst. Eng., UNL)
– Joe Turner (Eng. Mechs., UNL)
Charge:
• Your task is to develop core ideas/projects for an $8-10M
($1.25-1.5M per year for 5 years) NIH Center proposal.
– Catheter-based Ultrasound with Microbubbles
• Specifically, you should consider the following questions
Briefly describe the core projects your group
would design for the Center. Please dream big.
Intravascular Ultrasound with Targeted Microbubbles
• Microbubble enhanced ultrasound is normally done
only in regions where ultrasound imaging can be done
Project Focus:
• Use intravascular ultrasound (IVUS) with focused
beam profile to burst microbubbles in areas of the body
where ultrasonic imaging is not possible
• Introduce drug-laden microbubbles for targeted drug
delivery
• Diagnose delivery amount using IVUS-based targeted
tissue palpitation
Identify the key faculty from from both
campuses to involve in these projects. Include
their strengths. (UNMC on next slide)
• UNL Faculty
Strengths
Joe Turner (ultrasonic modeling)
Greg Bashford (ultrasonic imaging)
George Gogos (fluid flow)
Jiashi Yang (externally-guided bubbles/particles)
Mehrdad Negahban (in-vivo tissue characterization)
Li Tan (development of guidable particle)
Mehmet Can Vuran (wireless particle movement)
Sensor design expert
Identify the key faculty from from both
campuses to involve in these projects. Include
their strengths.
• UNMC Faculty
Strengths
Jason MacTaggart (vascular surgery)
Feng Xie (ultrasound/microbubbles)
David Holtzclaw (microfluidics)
Surgical Oncologist
Center for Nanomedicine Drug Delivery
Identify external academic partners & expertise
or equipment resources/strengths that are
needed to accomplish these projects.
List potential industry/foundation partners
(think broadly) and what they would contribute.
Include reasons why they would be interested.
Describe how you would link the Center to
other campus resources.