Transcript Document

HPTN 052
A Randomized Trial To Evaluate
the Effectiveness of Antiretroviral
Therapy to Reduce the Sexual
Transmission of HIV-1 in
Serodiscordant Couples
ART to Prevent Sexual
Transmission of HIV
1. Biological plausibility
2. Expectations from modeling
3. HPTN052
- Protocol Development
-Team Building (SOPs)
-Site Preparedness and Community Input
4. HPTN/ACTG “Marriage”…and ACTION
ITEMS
-HPTN052 Plus
5. ART for Prevention: limitations
HPTN 052 ACTION ITEMS
1. Improved infrastructure for 7 PTN sites
initiated
2. Piloting HPTN VCT and couples
counseling SOP
3. Piloting HPTN primary care services
4. Introducing HPTN ART care services
4. HPTN/ACTG Activities
HPTN052 Protocol Review Process
Development of HPTN 052 PLUS
ACTG/HPTN Expansion (RFA)
ACTG/HPTN Training
HPTN 052: The Best
Case Scenario
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Proof that ART prevents sexual transmission of
HIV, sustained
Identification of biomarkers that prospectively
predict transmission
Demonstration of safe and effective delivery of
ART, with benefit to the individual
Determination of the merits of early vs. late
ART
Expansion of prevention results that benefit
treatment and prevention activities
Identification of strategies to reduce the
probability of resistance
ART for Prevention in Developing
In
Countries
resourceA
limited
mountain
countries:
Supply
of limitations:
&
Demand
Enthusiasm
> 30 million
Cynicism, Skepticism
infected
Ethical and Economic issues
people
Logistical and Public health issues
Layers of governmental approval
IRB approval, Drug supply, Drug delivery
Patient management
In the West:
Required: Commitment and Tenacity