Transcript Conditioned Place Preference

Application of Conditioning to
the Study of Drug Addiction
Conditioned Place Preference with drugs of abuse uses
Pavlovian conditioning procedures
CS * UCS
CS
e.g. Light Stimulus*Drug
Light Stimulus
R
R
approach response
approach response
Self-Administration of drugs of abuse uses
Instrumental conditioning procedures
R
e.g. Lever press response
SR
drug delivery
Conditioned Place Preference
stay
Drug-injected
Not Drug-injected
don’t
stay
Pre-conditioning
Preference Tests
Days 1 and 2
Conditioning
Sessions
Days 3-10
Post-conditioning
Preference Tests
Days 11 and 14
Intravenous Cocaine Self-Administration
Some drugs that are self-administered by laboratory animals
Stimulants
Narcotics
Cocaine
Fentanyl
Anxiolytics
Chlordiazepoxide
Other
Phencyclidine (PCP)
d-Amphetamine
Heroin
Diazepam
Nicotine
Methylphenidate
Codeine
Pentobarbital
Ethanol
Methamphetamine Methadone
Morphine
Ketamine
D 9 THC
Self-Administration Model of Relapse incorporates both
Instrumental and Pavlovian Conditioning
No Cocaine and No Cues
Cocaine Cues Alone
Cocaine + Cocaine Cues
Cue-Induced Relapse to Cocaine-Seeking Behavior
Childress et al 1999
Cocaine Cue-Induce Craving
Front of Brain
Amygdala
not lit up
Amygdala
activated
Back of Brain
Nature Video
Cocaine Video
Grant et al 1996
Cocaine Cue-Induce Craving
In the laboratory......
• Study the brain sites that mediate conditioned relapse-like behavior
• Determine the molecules that give rise to conditioned relapse-like behavior
(e.g., genes; proteins)
• Test medications that may reduce conditioned relapse-like behavior
• Study the consequences of conditioned drug use
(e.g., neurocognitive; brain plasticity changes)