Transcript Mesporin: Mepha Health Care.. for Post

Mesporin:
Mepha Health Care..
for Post-operative Infection
The innovative Swiss pharmaceutical company
Headline of the presentation / July 16, 2015 / Page 2
Postoperative Infections,
Simple Facts
The innovative Swiss pharmaceutical company
Headline of the presentation / July 16, 2015 / Page 3
■ The most common postoperative infections include:
- Local infection:
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Surgical site (wound) infection,
Intra-abdominal infection & abcess,
- Remote infections:
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Respiratory tract infection,
Urinary tract infection,
 The rates of surgical site and respiratory
infections are less with laparoscopic
surgery; however, in some studies
laparoscopic surgery seems to cause a
higher incidence of postoperative intraabdominal abscess¹.
1: Boni et al; Infective Complications in Laparoscopic Surgery. Surgical
Infections. Summer 2006, 7(supplement 2): s-109-s-111.
The innovative Swiss pharmaceutical company
Headline of the presentation / July 16, 2015 / Page 4
Preventing Surgical Infections
Antibiotic prophylaxis
■ Drugs: which, when, how many doses?
Non antibiotic measures- evidence based:
Hair removal
Normothermia
Oxygen supplementation
Normoglycemia
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Headline of the presentation / July 16, 2015 / Page 5
Antibiotic rationale –
what should we choose?
■ Deal with the common pathogens
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encountered at the surgical site
One that is bactericidal
One that achieves adequate local
soft tissue concentrations
One that is non toxic with minimal
side effects
One that has a long serum half life
Ideally one that has a low risk of
inducing resistance
The innovative Swiss pharmaceutical company
Headline of the presentation / July 16, 2015 / Page 6
For such serious need in surgery…
has developed an innovative antibiotic..
The innovative Swiss pharmaceutical company
Headline of the presentation / July 16, 2015 / Page 7
Ceftriaxone Prophylaxis
General & Gynecological Surgery
The innovative Swiss pharmaceutical company
Headline of the presentation / July 16, 2015 / Page 8
■ Postsurgical infections varies in site, severity, & causative
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micro-organisms.
Therefore, 2 or 3 antibiotic combinations are usually used,
as well as broad & ultra-broad spectrum antibiotic
monotherapy.
To evaluate the role of surgical prophylaxis with
ceftriaxone versus other antibiotics, a meta-analysis of 48
clinical studies were performed involving 17, 565 patients*.
* Esposito et al; Ceftriaxone versus Other Antibiotics for Surgical Prophylaxis: A Meta-Analysis.
Clinical Drug Investigation: 2004 - Volume 24 - Issue 1 - pp 29-39.
The innovative Swiss pharmaceutical company
Headline of the presentation / July 16, 2015 / Page 9
Results:
Incidence of postoperative infections
The innovative Swiss pharmaceutical company
Headline of the presentation / July 16, 2015 / Page 10
Conclusions:
■ The meta-analysis showed that ceftriaxone is statistically
superior to other antibiotics in preventing both local and
remote postoperative infections.
The innovative Swiss pharmaceutical company
Headline of the presentation / July 16, 2015 / Page 11
The antibiotic of choice
Once daily therapy
The innovative Swiss pharmaceutical company
Headline of the presentation / July 16, 2015 / Page 12
TM
Mesporin
Ceftriaxone
MesporinTM
is a sterile, lyophilized, semi-synthetic, long-acting, parenteral (intravenous
and intramuscular), broad-spectrum bactericidal antibiotic.
The chemical formula of ceftriaxone sodium
References:
Zimmermanns M. Index Infektionen Erreger Antibiotika. 1989
Headline of the presentation / July 16, 2015 / Page 13
TM
Mesporin
Ceftriaxone
Properties and effects
The bactericidal activity of ceftriaxone results from inhibition of the
bacteria’s wall synthesis.
Ceftriaxone exerts activity against both Gram-negative and
Gram-positive aerobic and wide range of anaerobic microorganisms.
Ceftriaxone is highly stable to most β-lactamases, both penicillinases and
cephalosporinases, of Gram-negative and Gram-positive bacteria.
References:
Zimmermanns M. Index Infektionen Erreger Antibiotika. 1989
Headline of the presentation / July 16, 2015 / Page 14
TM
Mesporin
Ceftriaxone
Pharmacokinetics of ceftriaxone
Half-life of ceftriaxone is generally about 6 to 10 hours in
healthy adult subjects.
The exceptional pharmacokinetic characteristics of ceftriaxone
(MesporinTM) supports a once-daily dosing in every clinical
conditions and patient age.
A high plasma and tissue concentration after both i.v. and i.m.
administration simplifies the treatment and ensures an effective
bactericidal tissue concentration during 24 hours.
References:
Physician’s Desk Reference. 54th edition, 2000
Borgden R., Ward A. Drugs. 1988;35;604–645
Patel I. et al. Antimicrob Agents Chemother. 1981;20;634–641
Stoeckel et al. Current Chemotherapy and immunotherapy. 1982;Vol.1;454–455
Headline of the presentation / July 16, 2015 / Page 15
The antibiotic of choice
 Compensatory excretion through the kidney and liver
prevents accumulation in case of impairment of one or
the other.
 Dual and balanced excretion Via Renal and Biliary pathways
The innovative Swiss pharmaceutical company
Headline of the presentation / July 16, 2015 / Page 16
Why Mesporin?
ONCE DAILY
TOP SWISS QUALITY
Lyophilized ceftriaxone
Deep tissue penetration
Dual excretion pathways
The innovative Swiss pharmaceutical company
Thank You
The innovative Swiss pharmaceutical company