Diapositiva 1 - Research Programme on Biomedical Informatics

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Transcript Diapositiva 1 - Research Programme on Biomedical Informatics

Hands - on
Project idea
The process of discovery and development of drugs is ever longer and costly.
It happens in an environment of research teams from different organizations
(coming from the pharmaceutical industry, academia, SMEs, etc.) often
placed in distant locations where there the need for constant discussions
and interactions. Those communications seldom take place based on
graphical elements (3D, 2D, images…) that might require strict confidentiality
due to their high industrial value. Consequently, the majority of interactions is
performed in presence meetings, which is costly and time consuming.
The idea is to develop a software that enables research teams from the drug
discovery and development sector (pharmaceutical, biotechnological, etc) to
collaborate from a distance and discuss in real time over graphical elements
(3D molecules, result tables, images, etc.) without the need of face-to-face
meetings so often, accelerating the entire process.
Hands - on
Basic Characteristics
• Small-medium collaborative project
• Funding: around 3.000.000 €
• Length: maximum of 3 years
• Related fields: IST – eHealth, IST – eWork, GROWTH, Quality of
Life, etc. Possible topics:
• IST II.2.2: New methods of work and electronic commerce - Smart organisations
To explore and validate novel technologies, applications, architectures and practices
aimed at supporting the transformation of profit and non-profit entities into "smart"
organisations: knowledge driven, internetworked, dynamically adaptive to new
organisational forms and practices, learning as well as agile in their ability to create and
exploit the opportunities offered by the digital economy.”
• IST II.1.5: Promoting broad adoption of eCommerce & eWork in regional and sectoral
settings.
• GROWTH 1.4.1: New methods of organisation, work and human capital improvement
The aim is to develop new organisational and work practices together with developments
in industrial products, processes and services, and the appropriate human capital,
competence and skills. RTD should address methodologies and tools for efficient
organisation, knowledge and technology management, and support close integration and
networking of people, organisations and technologies, recognising the importance for
innovation / competitiveness of better procurement methods and decision making tools.
Hands - on
Potential Partners
Name
Type
Country
Expertise
Profile
Fundació Biomèdica
(FBM)
Non-profit research
centre
Spain
Modelling 3D, software, drug discovery
research
-
Lab. Vida S.A. (LV)
Private company
Spain
Pharmaceutical company
Usual collaborator
IBMF Technologies
(IBMF)
Private company
UK
Software / hardware development
generic
Known
Università de Milano
(UMI)
Academia
Italy
Drug discovery research
Unknown – Guru
Universidade Santiago
de Compostela (USC)
Academia
Spain
Drug discovery research
Usual collaborator
AstraSeneca (AS)
Private company
Sweden
Top pharmaceutical company
Unknown
Drug Discovery
Software Srl (DDS)
Private company –
SME
Italy
Molecular software development
Known
Joint Research Center
(JRC)
European
Commission
Europe
Generic software research
Unknown
Digital Security UK
(DIGI)
Private company
UK
Security, encryptation
Unknown
Universitat de
Catalunya (UCAT)
Academia
Spain
Software development
Known – Guru
Instituto de Tecnología
de Murcia (ITM)
Non-profit research
centre
Spain
Security, encryptation
Usual collaborator
University of Bremen
(UBR)
Academia
Germany
Molecular software development, drug
discovery research
Unknown – Guru
Microsoluciones SL
(MICRO)
Private company –
SME
Spain
Software development (generic)
Usual collaborator
Transgen SL (TGEN)
Private company
France
Biotech
Unknown
University of Düsseldorf
(UD)
Academia
Germany
Drug discovery research
Usual collaborator
Hands - on
Exercise 1
1) List the objectives of the project
2) Select an acronym
3) Choose the partners for the consortium
Hands - on
WRAP-UP 1
Project objectives
LINK3D aims to develop, test and prepare the commercial exploitation of
a real-time, interactive distant collaboration environment for professionals
working in an strategically crucial field: Molecular Discovery (MD). The
specific objectives of the project are:
1) To gather detailed requirements of MD professionals in terms of tele
collaboration.
2) To develop a set of software applications, configuring a real-time telecollaboration environment for Drug Discovery professionals.
3) To test the system in real-life environments, both for interorganisational and intra-organisational collaborative settings and
considering the different types of actors involved (industry, academia).
4) To analyse the potential market, the business possibilities of the
LINK3D system, and prepare its commercial exploitation, considering
extension to other sectors.
Hands - on
WRAP-UP 1
Partners LINK3D:
Name
Type
Country
Expertise
Profile
Fundació Biomèdica
(FBM)
Non-profit research
centre
Spain
Modelling 3D,
software, drug
discovery research
-
Lab. Vida S.A. (LV)
Private company
Spain
Pharmaceutical
company
Usual collaborator
AstraSeneca (AS)
Private company
Sweden
Pharmaceutical
company
Unknown
Drug Discovery
Software Srl (DDS)
Private company –
SME
Italy
Molecular software
development
Known
Digital Security UK
(DIGI)
Private company
UK
Security, encryptation
Unknown
Universitat de
Catalunya (UCAT)
Academia
Spain
Software development
Known – Guru
University of
Düsseldorf (UD)
Academia
Germany
Drug discovery
research
Usual collaborator
Hands - on
Exercise 2
1) List the Work Packages
2) Define Deliverables and Milestones
3) Assign Work Packages Leaders
Hands - on
WRAP-UP 2
List of Work Packages:
WP1
Project management and co-ordination (FBM)
WP2
User requirements gathering (FBM)
WP3
System specifications (DDS)
WP4
System development (UCAT)
WP5
In-process testing (DDS)
WP6
Real-world testing (FBM)
WP7
Exploitation (DDS)
WP8
Dissemination (FBM)
WP9
Assessment and evaluation (FBM)
Hands - on
WRAP-UP 2
Tasks:
WP1
Project management and co-ordination (FBM)
T1.1. Day to day operational management
T1.2. Project co-ordination
WP2
User requirements gathering (FBM)
T2.1 Planning
T2.2 Execution
T2.3 Analysis of results
WP3
System specifications (DDS)
T3.1 File formats
T3.2 Communication protocols
T3.3 Security issues
T3.4 Definition of standard hardware configuration requirements
T3.5 Global definition of the system specifications
Hands - on
WRAP-UP 2
Lista de Tasks:
WP4
System development (UCAT)
T4.1 Development of the communication protocols
T4.2 Development of the whiteboard metaphors and graphical engines
T4.3 Development of the security
T4.4 System adjustments
T4.5 User manuals
WP5
In-process testing (DDS)
T5.1 Planning
T5.2 Execution
T5.3 Analysis of results
Hands - on
WRAP-UP 2
Tasks:
WP6
Real-world testing (FBM)
T6.1 Testing planning (inter-organisational setting)
T6.2 Testing execution (inter-organisational setting)
T6.3 Analysis of results (inter-organisational setting)
T6.4 Testing planning (intra-organisational setting)
T6.5 Testing execution (intra-organisational setting)
T6.6 Analysis of results (intra-organisational setting)
T6.7 Integration of testing results
WP7
Exploitation (DDS)
T7.1 Market analysis
T7.2 IPR issues
T7.3 Business plan
T7.4 Extension to other industrial sectors
Hands - on
WRAP-UP 2
Tasks:
WP8
Dissemination (FBM)
T8.1 Web site
T8.2 Brochure
T8.3 Other activities
WP9
Assessment and evaluation (FBM)
T9.1. Quality assurance
T9.2. Risk management
T9.3. Project evaluation
Hands - on
WRAP-UP 2
Deliverables list:
Del. no.
Deliverable name
WP
no.
Del. type*
Delivery
(proj.
month)
D1
Report on the set-up of the organisation and
infrastructure of the LINK3D project
1
Report
3
D2
Project presentation
8
Document
3
D3
Report on user requirements (investigation
methods and results)
2
Report
4
D4
Dissemination and use plan
8
Report
6
D5
Report on the specifications of the LINK3D system
3
Specification
7
D6
First version of the LINK3D system including user
manuals
4
Prototype
19
D7
Report on the in-process testing (methods and
results)
5
Report
19
D8
First report on real-world testing of the LINK3D
system (methods and results)
6
Report
22
D9
Report on the specifications of the improved
LINK3D system
3
Specification
23
D10
Report on market analysis
7
Report
24
D11
Improved version of the LINK3D system including
user manuals
4
Prototype
26
D12
Final report on real-world testing of the LINK3D
system (methods and results)
6
Report
29
D13
Final report on dissemination activities
8
Report
30
D14
Report on the business plan
7
Report
30
D15
Assessment and evaluation report
9
Report
30
Hands - on
WRAP-UP 2
Milestones list:
M1
Definition of user requirements
M2
Completion of the system specifications (first version)
M3
Completion of the first version of the LINK3D system
M4
Completion of the first stage of the real-world testing
M5
Completion of the market analysis
M6
Completion of the improved system specifications
M7
Completion of an improved version of the LINK3D system
M8
Completion of the second stage of the real-world testing
M9
Completion of the business plan
M10
LINK3D project completion
Hands - on
Exercise 3
1) GANTT chart
2) PERT diagram
Hands - on
WRAP-UP 3
Hands - on
Exercise 4
• Responsibility Assignment Matrix, defined by
project roles
R: Responsible
W: Major contribution
I: Minor contribution
Hands - on
WRAP-UP 4: RAM LINK3D
FMB
LV
AS
WP1 - Project Management and
Coordination
R
WP2 - User requirements gathering
R
WP3 - System specifications
I
WP4 - System development
W
WP5 - In-process testing
R
I
I
WP6 - Real-world testing
R
W
W
WP7 - Exploitation
W
WP8 - Dissemination
R
WP9 - Assessment and evaluation
R
DDS
DIGI
W
W
UD
W
W
W
R
I
UCAT
W
W
W
W
R
W
W
I
W
R
W
I
I
I
I
I
I
I
I
I
I
Hands - on
Exercise 5
• RAM of efforts
• 3 steps:
• Relative weight of each WP
• Estimate the total effort amount
• Estimate the breakdown of efforts per task
Hint: the total amount can be estimated dividing
the total funding by 5000-10000 Euro
(depending on the consortium profile).
Hint: Estimate the relation between R, W, I:
• W= 2 I
• R= 3 I
Hands - on
WRAP-UP 5: RAM LINK3D
FMB
LV
AS
WP1 - Project Management
and Coordination
15
WP2 - User requirements
gathering
17
WP3 - System specifications
4
WP4 - System development
36
WP5 - In-process testing
13
4
4
WP6 - Real-world testing
35
23
23
WP7 - Exploitation
13
WP8 - Dissemination
8
WP9 - Assessment and
evaluation
11
DDS
DIGI
10
11
UD
10
11
11
13
3
UCAT
8
pm
total
pm
target
Weight
WP
35
35
7
50
50
10
9
9
35
35
7
36
54
125
125
25
8
8
4
50
50
10
23
105
105
21
50
50
10
25
25
5
25
25
5
500
100
19
13
6
3
3
3
3
4
4
4
4
3
total pm
151
41
45
57
72
93
41
500
Full-time Equivalents (FTE)
4,2
1,1
1,2
1,6
2,0
2,6
1,1
13,9
Hands - on
Exercise 6
• Construct the budget
• Take into account the type of expenditure:
personnel, equipment, consumables, travel,
subcontracting, indirect costs.
• Take into account that funding agencies do
not always cover 100% of the direct costs of
the project (difference between “budget” and
“funding”).
Hands - on
WRAP-UP 6: Budget LINK3D
FMB
LV
AS
DDS
DIGI
UCAT
UD
total pm
151
41
45
57
72
93
41
Full-time Equivalents (FTE)
4,2
1,1
1,2
1,6
2,0
2,6
1,1
4000
4500
6000
5500
7000
3500
3900
0,6
0,45
0,3
0,6
0,6
0,6
0,6
45000
30000
30000
45000
30000
45000
30000
104
39
39
21
53
71
39
417024
173750
231667
118021
369583
247292
150583
Other direct costs
31110
27987
25763
17073
22107
34095
27987
Overheads max.
268880
78188
77229
81056
235014
168832
107142
Total costs
717014
279924
334659
216151
626705
450218
285712
EC contribution
537761
139962
167330
162113
313353
337664
214284
15
0
0
10
0
10
0
Personnel costs
60000
0
0
55000
0
35000
0
Subcontracting
2000
0
0
1000
1000
1000
0
Other direct costs
4476
0
0
7956
0
4826
0
Overheads max.
38686
0
0
37774
0
23895
0
Total costs
105162
0
0
101730
1000
64721
0
EC contribution
105162
0
0
101730
1000
64721
0
Average personnel rate
Overhead rate
Other costs (travel, consumables,
etc.)
RTD
total pm
Personnel costs
Subcontracting
Management
total pm
Hands - on
WRAP-UP 6: Budget LINK3D
Other
FMB
LV
AS
DDS
DIGI
UCAT
UD
32
3
6
25
19
13
3
126190
12500
38095
138046
131944
44097
10833
Other direct costs
9414
2013
4237
19970
7893
6080
2013
Overheads max.
81363
5625
12700
94809
83902
30106
7708
Total costs
216967
20138
55031
252825
223739
80283
20555
EC contribution
216967
20138
55031
252825
223739
80283
20555
151
41
45
57
72
93
41
500,0
Personnel costs
603214
186250
269762
311066
501528
326389
161417
2359626
Subcontracting
2000
0
0
1000
1000
1000
0
5000
Other direct costs
45000
30000
30000
45000
30000
45000
30000
255000
Overheads max.
388929
83813
89929
213640
318917
222833
114850
1432910
Total costs
1039143
300063
389690
570706
851444
595222
306267
4052536
TOTAL
COSTS
EC contribution
859889
160100
222361
516669
538092
482668
234839
3014618
TOTAL
FUNDING
total pm
Personnel costs
Subcontracting
TOTAL
total pm