Spectrum`s mission is to provide quality Membrane Separations

Download Report

Transcript Spectrum`s mission is to provide quality Membrane Separations

Spectrum’s mission is to provide quality
Membrane Separations Technology to
the Life Science market
Tangential Flow
Filtration
Shanghai, Oct. 26, 2011
Yingqing Huang, General Manager for Greater China
Overview
Introduction to TFF
Applications
Challenges
Our Offerings
– Membranes, mPES,
– System, KRIIi
– Single Use Technology
• Designed for Scalability
• Summary
•
•
•
•
Hollow Fiber TFF
• Effective Reduction of Membrane Fouling
• Tubular Membrane Geometry
• Large Surface Area in a Compact Size
• Gentle Separations with
Relatively Low Pressure
• Available in UF and MF pore size ranges
• Directly Scalable by
Increasing Number of Fibers
Applications
•
•
•
•
•
•
Alternatives to centrifugation, depth filtration, etc.
Separation
Purification
Sterilization
Buffer exchange
Concentration
Industries
Company
Application
MERCK
Drug delivery, vaccines
ACCELERON PHARMA
Theoepeutical rProteins, IgG
NOVARTIS VACCINES & DIAGNOSTICS
E.Coli concentration
SAIC FREDERICK
Vaccines
BAXTER HEALTHCARE CORP.
Pertusis, Mening C
MEDIMMUNE
Vaccines
ABBOTT LABORATORIES
Diagnostics
INTEGRA BIOLOGICS
Bone Repair
AMGEN, INC.
Cell Perfusion
ROCHE DIAGNOSTICS
Diagnostics, latex
NANOSPECTRA BIOSCIENCES, INC.
Gold nanoparticles
BECKMAN COULTER, INC.
Diagnostics
GENENTECH INC
Cell Culture, drug development
REFINE
Perfusion
STEMCELL TECNOLOGIES
Particle concentration / reactor
Permeate Flow
Challenges
•
•
•
•
•
Membrane fouling
Pressure, flow, TMP, recirculation
System configuration
Interactions of parameters
Scale up loopholes
Operation Time
Our Offerings
• Wide range of membrane selections to meet
diversified applications
– Materials, SA, Pore size, Geometry, etc.
• Systems for both R&D and productions
• Pre-assembled Membrane, Bags, and Tubing
packages to improve your efficiencies
• Direct tech support from application experts
Spectrum Hollow Fiber Modules
• Broadest Range of MWCO’s (1kD through 0.65 µm)
• Membrane Types = PS, mPES, ME, RC, PP
• Small Scale = MicroKros (5 cm2)
• Large Scale = KrosFlo Max module (22 m2)
• Sterile, Non-Sterile
Benefits of mPES Membranes
Characteristics
Benefits
• Hydrophilic membrane
• Easier R & D
• Low protein binding
& slow fouling
• Stable operations
• High selectivity
• Cost effective
• High permeability
• High performance
KRIIi makes R&D
Easier
• Provides all necessary
components for your study
• Automated TMP control
• Real time data collection and
graphic analysis
• Small footprint
• Provide solid data for scale up
• Ideal for R&D and low volume
production
KF Comm Data Collection System
• Process data exports directly into MS
Excel in real time
• Calculated feed flow rate , shear, TMP,
etc.
• Customizable alarm setting for process
safety
• Pressure control with non-invasive
valves
• Real-time graphing (virtual recording)
• Make the most of your experiment
• Recorded data for analysis
MBT Assemblies
Permeate Flow Meter
Pressure Transmitter
MBT Assemblies
• Reduce your setup or
preparation time
• Reduce process variability
• Reduce your logistics
burden
• Improve your efficiencies
and productivity
Designed for Scalability
• Membrane module sizes
• Customizable
Designed for Scalability
• Complete line of process systems
• KF Comm Date Collection System
generates solid data for scale up
• Scale up guided by technical
sound rationales
KrosFlo Research IIi
KrosFlo MiniKros Pilot
KrosFlo LDF-55
MBT Systems for different scales
• Compatible with KFComm
data collection systems.
• Customizable and optimized
system setup and
configuration for different
systems
–
–
–
–
KR2i – Bench Scale
KMP – Pilot Scale
LDF37 – Production
Khameleon Perfusion
Systems
SUMMARY
• Wide selection of membranes including our unique offering of high
performance mPES membrane.
• KRIIi research TFF system make your R&D easier.
• Single use MBT system improve your efficiency
• Complete product line and common data collection software ensures
smooth transfer for R&D to production.
• Direct onsite technical service available
• Competitive price
Thank You
多谢光临