Transcript Lesson 8- Bioavailablility Lecture unit2Lesson8x

Parenteral
Oral
Insufflation
SOURCE: Juan Salinas, Ph.D.
– Psych 308 – U. Texas
http://www4.d25.k12.id.us/
Circulatory system
Blood distribution is not
uniform, why?
Mouth  gut
Gut  blood
Blood  heart
Heart  lungs
Lungs  heart
Heart  brain
How many stops
before the
brain?
Lungs  heart
Heart  brain
1.
2.
3.
4.
5.
The placental barrier
The blood brain
barrier
The hepatic barrier
The lung barrier
The skin barrier
Therapeutics that we have trouble
getting into the brain
Example – treating Parkinson’s
with needed dopamine – must use Ldopa precursor. Not as effective.
Fix – MICROBUBBLES and
ULTRASOUND PULSES  open
barrier!
1.
2.
3.
4.
5.
Usually proteins
Molecules that help make
chemical bonds
Molecules that help break
chemical bonds
Found inside living cells
All of the above
 What is the name of the enzyme you studied in the lab?
 What is its job?
 Did all foods exhibit the same “activity” of that enzyme?
 Why might one food have more of it than another?
 When the samples were heated, they reacted mare
slowly, or not at all. How can you explain this?
 What were the controls we performed to ensure we could
make a comparison between food types?
 Check through lab and make sure ALL questions are
answered. You will turn in pre-lab and lab w/QUIZ
 Your ideas
 Which is more addictive, snorted cocaine or crack
cocaine? Crack
 Which vitamins are fat soluble? DEAK
 What category of molecules is responsible for drug
metabolism? enzymes
 Where are these metabolic enzymes produced? liver
 Previously learned material
 What is the main difference between fats and other
biological molecules? Lipids are hydrophobic
 What are glial cells? Non-neuronal cells of the
nervous system that support nervous system function.
CYP-450 mixed-function oxidase
family (big group)
CYP3A4 = family member that
metabolizes ½ of all prescription
drugs
Inactive
drug
Drug metabolism

Metabolism
via enzyme
Cytochrome P450 family
CYP2A6
Drug metabolism
ALDH
CYP3A11
How MUCH enzyme is present?
How EFFICIENT is the enzyme?
Is drug FAT SOLUBLE
Fat soluble drugs = benzodiazepines, Marijuana, PCP, others
Related to administration, metabolism and
elimination and fat solubility!
Drug in system
100%
50%
0%
Time
1.
2.
3.
4.
5.
Fat soluble > water
soluble
Oral administration >
parenteral administration
Nicotine > Marijuana
Metabolized by efficient
enzyme > metabolized by
inefficient enzyme
Can cross blood brain
barrier > cannot cross